摘要
对14头健康小型猪分别进行开腹(open cystostomy,OC)、腹腔镜膀胱造口手术(laparoscopic cystostomy,LC),通过检测小型猪术后不同时间点血清皮质醇(cortisol,COR)、白介素-6(Interleukin-6,IL-6)和C反应蛋白(C-reactive protein,CRP)的变化,比较OC手术与LC手术对机体应激反应的影响。结果表明,LC、OC2组分别在不同时间点所检测到的的COR、IL-6和CRP与试验前相比,都有极显著性差异(P<0.01)。在术后即刻和4h后OC组对应激指标的影响要明显高于LC组,并且术后3dLC组都恢复到试验前水平,而OC组术后5d才恢复。说明LC和OC都可导致血清中COR、IL-6、CRP水平的升高,但OC较LC对COR、IL-6和CRP的影响更为显著,即腹腔镜膀胱造口手术比开腹膀胱造口手术对机体应激反应的影响更小。
Fourteen healthy miniature pigs were undergo laparoscopic cystostomy(LC)and open cystostomy(OC),respectively.Stress response was compared between the two groups by detecting the serum cortisol(COR),interleukin-6(IL-6)and C-reactive protein(CRP)of the different time points after surgery.The results show that serum COR,IL-6and CRP in the LC and OC group have extremely significant changes at different time points compared with pre-operation(P<0.01).At immediately and 4hafter surgery,the stress response in the OC group were significantly higher than that of LC group,and the stress index restored to the level of pre-operation at 3dafter surgery in the LC group,while the OC group resumed after 5d.This suggested that LC and OC can lead to increase of serum COR,IL-6and CRP levels,but OC has a more significant effect.
出处
《中国兽医学报》
CAS
CSCD
北大核心
2014年第12期2005-2008,共4页
Chinese Journal of Veterinary Science
基金
高等学校博士学科点专项科研基金资助项目(20102325110003)
东北农业大学博士科研启动基金项目(2009RC60)
关键词
腹腔镜
膀胱造口手术
小型猪
应激反应
laparoscope cystostomy
open cystostomy
miniature pigs
stress response
