摘要
近5年来中药界学人发现22种中药成分可有效保护内皮祖细胞(EPCs)。分别通过调节氧化应激反应、抑制EPCs凋亡、阻遏炎症因子的分泌、增强EPC动员、迁移、分化等生物学功能发挥对EPCs的保护作用。对此做系统论述及整理,并总结目前研究中存在的问题及以后的研究方向。
In the past five years,Chinese medicine scholars have newly discovered 22 traditional Chinese medicine ingredients to effectively protect endothelial progenitor cells.They can protect EPCs by regulating oxidative stress response,inhibiting apoptosis of EPCs,suppressing the secretion of inflammatory factors,and enhancing the biological functions of EPC mobilization,migration and differentiation.This paper makes a systematic discussion and collation,and summarizes the existing problems and future research directions.
作者
李鑫飞
桑晓宇
周继栋
李伟
赵启韬
LI Xinfei;SANG Xiaoyu;ZHOU Jidong;LI Wei;ZHAO Qitao(School of Pharmaceutical Sciences,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;School of Basic Medicine,Shandong University of Traditional Chinese Medicine,Jinan 250355,China)
出处
《药物评价研究》
CAS
2019年第5期1010-1013,共4页
Drug Evaluation Research
基金
国家自然科学基金项目(81173164及81573852)
山东省教育厅高等学校科研项目(J10LF54)
关键词
内皮祖细胞
氧化应激
炎症因子
生物学功能
endothelial progenitor cells
oxidative stress
inflammatory factors
biological functions
