摘要
目的 :聚氨酯作为与血液接触的植入物和组织器官替代材料在心血管系统有重要而广泛的应用前景 ,本研究采用等离子体表面接枝技术 ,通过“空间桥梁”在聚氨酯材料表面引入具有抗凝血功能的肝素分子 ,对材料表面的微观化学组成、表面接触角等理化性能进行了测定分析 ,并通过测定血小板在材料表面的粘附数量 ,对改性表面的抗凝血性能做了评价。结果 :聚氨酯表面接枝肝素分子后 ,表面的氧 /氮元素比提高 ,水接触角减小 ,对血小板的吸附和活化性下降 ,抗凝血性能得到提高。
Objective: Polyurethane is a kind of important blood-contacting biomaterial in cardiac vascular surgery. Aiming at improving the hemocompatibility, heparin was selected on to be introduced on to the polyurethane surface. Method: Heparin was incorporated onto the polyurethane surface through a 'spacer' utilizing plasma glow discharge technology. The surface chemistry and the contact-angle were measured, and the hemocompatibility evaluated through platelet adhesion tests. Results: The heparin molecules were incorporated onto the material surface through covalent bonds, the water contact angles were decreased, the relative oxygen contents increased, and the number of platelets adhering to the surface was reduced. Conclusion: Heparin molecules could be incorporated onto the polyurethane surface by covalent bonds through plasma glow discharge technology and the surface properties changed to some extent, the blood compatibility of modified surface was improved as platelets adhesion to the surface was suppressed.
出处
《中国生物医学工程学报》
CAS
CSCD
北大核心
2003年第6期533-536,共4页
Chinese Journal of Biomedical Engineering
基金
国家自然科学基金重点资助项目 ( 3 983 0 12 0 )
