摘要
目的 :评价前程加用化疗后程加速超分割放射治疗食道癌的疗效与毒性 .方法 :对符合入组条件的 1 0 0例病例 ,随机分为单放组 5 0例和化放组 5 0例 .单放组前程常规分割放射 30Gy ,后程加速超分割放射 30Gy ,每次 1 .5Gy ,每天 2次 ,间隔 6h以上 .化放组前程在单放组放射治疗基础上每周六静脉输注顺铂 5 0mg ,5氟脲嘧啶 5 0 0mg ,共 3wk ,后程同单放组 .结果 :化放组和单放组的 1 ,2a生存率分别为86 .0 % ,78.0 % ,78.0 %和 6 6 .0 % ,但无统计学差异 (P >0 .0 5 ) .肿瘤局部控制率加用化疗后提高 ,化放组和单放组 1 ,2a局部控制率分别为 82 .0 % ,72 .0 %和 6 0 .0 % ,4 0 .0 % ,两组比较统计学上有显著差异 (P <0 .0 5 ) ;毒副反应化放组较单放组高 ,但患者一般均能耐受 ,未见心、肝、肾的功能损害 .结论 :前程加化疗后程加速超分割放射治疗能明显提高食道癌的局部控制率 。
AIM: To assess the effects and toxicity of early course concurrent chemotherapy plus late course accelerated hyperfractionation radiotherapy (LCAHR) on esophageal carcinoma. METHODS: 100 patients with squamous carcinoma of thoracic esophagus were divided randomly into two groups: 1. LCAHR group, in which patients were irradiated 2.0 Gy/f, 5 times a week to a total does of 30 Gy early course and then irradiated by 1.5 Gy/f, 2 times a day (at more than 6 hours interval) to the total dose of 60 Gy; 2. C + LCAHR group, in which the radiotherapy technique was the same as the LCAHR group, but weekly 50 mg DDP and 500 mg 5 Fu were added simultaneously for 3 weeks in the early course. RESULTS: The 1 and 2 year survival rates were 86.0% and 78.0% in the C + LCAHR group, and 78.0% and 66.0% in the LCAHR group ( P >0.05). The 1 and 2 year local control rates were 82.0% and 72.0% in the C + LCAHR group, and 60.0% and 40.0% in the LCAHR group ( P <0.05). The acute toxic effect was severer in the C + LCAHR group than that in the LCAHR group, but all patients could tolerate them. No cardiac, hepatic and renal injury was found. CONCLUSION: Early course concurrent chemotherapy and late course accelerated hyperfractionation radiotherapy in the treatment of esophageal carcinoma can significantly improve the local control of esophageal carcinoma, but the long term survival rate needs further follow up.
出处
《第四军医大学学报》
北大核心
2003年第22期2100-2103,共4页
Journal of the Fourth Military Medical University
