摘要
[目的]观察通脑丸干预脑动脉硬化症慢性脑缺血损伤影响。[方法]使用随机平行对照方法,将随机选取的10只以及造模成功的40只清洁级Wistar大鼠编号按随机数字表分组法分为五组,10只/组;模型组灌胃生理盐水3mL/d,步长脑心通组给予步长脑心通悬浮液0.4g/kg·d,通脑丸高剂量组2.7g/kg·d,通脑丸低剂量组0.9g/kg·d,1次/d,连续14周。观测指标大鼠总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平。[结果]干预第14周,与模型组比较,步长脑心通组、通脑丸高、低剂量组的TC、TG、LDL-C均有显著降低,HDL-C显著升高(P<0.05);与步长脑心通组比较,通脑丸高、低剂量组的TC、TG、LDL-C三项血脂指标降低显著,HDL-C则显著升高;通脑丸组内比较,高剂量组优于低剂量组(P<0.05)。[结论]通脑丸干预脑动脉硬化症慢性脑缺血损伤效应与步长脑心通相似。
[Objective]To Relation of Tongnaowan treatment for i cerebral arteriosclerosis of chronic cerebral ischemia rats blood lipid changes in a randomized controlled.[Methods]Using randomized controlled Methods,will be randomly selected from 10 as well as the successful model of the 40 Wistar rats of clean grade number randomly grouping method were randomly divided into five groups,10 in each group;model group were perfused with physiological saline 3ml/d,step Naoxintong group with Buchangnaoxintong suspension of 0.4g/kg·d,Tongnaowan high dose group of 2.7g/kg·d,Tongnaowan low dose group 0.9g/kg·d.14 weeks in a row. The observation indexes of serum total cholesterol(TC),triglyceride(three TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)levels.[Results]After fourteenth weeks,compared with the model group,Naoxintong group,Tongnaowan high,low dose groups of TC,TG,LDL-C decreased significantly,HDL-C increased significantly(P<0.05);compared with Buchang Naoxintong group,Tongnaowan high,low dose groups of TC,TG,LDL-C three blood indexes decreased significantly,HDL-C increased significantly;the Tongnaowan high dose group is better than the low dose group(P<0.05).Conclusion:Tongnaowan on cerebral arteriosclerosis in rats of clean grade Wistar chronic cerebral ischemia damage effect and Buchang Naoxintong similar.
出处
《实用中医内科杂志》
2013年第6S期85-86,共2页
Journal of Practical Traditional Chinese Internal Medicine
