摘要
目的:探讨胃癌患者血清中人表皮生长因子受体-2 (Human epithelial growth factor receptor 2, HER2)HER-2、血管内皮生长因子(Vascular endothelial growth factor,VEGF)、低氧诱导因子-1α(hypoxia inducible factor-1, HIF-1α) mRNA水平与其临床特征及预后的关系。方法:选取我院2015年7月至2016年7月治疗的50例胃癌患者作为研究对象,采用荧光定量PCR检测血清中HER-2、VEGF、HIF-1α mRNA水平,探讨其与胃癌患者临床特点的关系,采用COX回归模型探讨HER-2、VEGF、HIF-1α mRNA表达与胃癌临床预后的关系。结果:胃癌组患者血清中HER2、VEGF、HIF-1α mRNA水平明显高于对照组患者,年龄越高、分化程度越低、临床分期晚、伴有淋巴结转移的胃癌患者血清中HER2、VEGF、HIF-1α mRNA水平明显高与相对应的患者,HER-2(P=0.04)、VEGF(P=0.03)、HIF-1α(P=0.04)是胃癌患者预后不良的独立危险因素。结论:胃癌组织中HER-2、VEGF、HIF-1α mRNA表达水平与胃癌恶性程度密切相关。
Objective: To investigate the relationship between HER-2, VEGF and HIF-1α levels in serum and clinical prognosis in patients with gastric cancer. Methods: In our hospital from July 2015 to July 2016 in 50 cases of gastric cancer patients treated in our hospital as the research object, using SP method and enzyme-linked immunosorbent assay in gastric cancer tissues and serum HER-2, VEGF and HIF-1α mRNA levels to explore the relationship between serum and tissue of patients with gastric cancer HER-2, VEGF, HIF-1α mRNA levels and clinical characteristics of patients with COX. HER-2, VEGF, regression model to investigate the relationship between HIF-1α expression and clinical prognosis of gastric cancer. Results: The serum of gastric cancer patients in the HER2, VEGF and HIF-1α mRNA levels were significantly higher than that in control group, comparison of different age, degree of differentiation, clinical stage HER2, VEGF and HIF-1α mRNA levels in the serum of patients with age is higher, the lower the degree of differentiation, clinical stage,lymph node metastasis in patients with serum HER2, VEGF and HIF-1a mRNA significantly patients with high contrast, HER-2(P=0.04), VEGF(P=0.03), HIF-1α(P=0.04) is an independent risk factor of poor prognosis of patients with gastric cancer. Conclusion: Serum levels of HER-2, VEGF and HIF-1a mRNA are closely related to the malignant degree of gastric cancer, which is an independent risk factor for poor prognosis of gastric cancer patients.
作者
周颖
杨静
陆丽华
许琦华
赵滨
ZHOU Ying;YANG Jing;LU Li-hua;XU Qi-hua;ZHAO Bin(Department of Gastroenterology,Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,200137,China;Department of general surgery,Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,200137,China)
出处
《现代生物医学进展》
CAS
2018年第24期4703-4706,共4页
Progress in Modern Biomedicine
基金
浦东新区卫生系统学科带头培养计划项目(PWRd2016-12)
上海市卫生和计划生育委员会科研课题资助项目(2016460309)
上海中医药大学附属第七人民医院人才培养计划(BDX2016-01)
(XX2015-07)
(QMX2016-04)
关键词
胃癌
转移
复发
化疗
Gastric cancer
Metastasis
Recurrence
Chemotherapy
