摘要
目的 观察CHF患者血浆肿瘤坏死因子和受体水平的变化及适量步行运动对其的影响,并探讨适量步行运动对慢性心力衰竭患者的治疗价值。方法 将142例心功能Ⅱ、Ⅲ级的(2H17患者随机分为运动组(常规+运动,86例)和对照组(常规,56例)。运动治疗方法:运动组入组后,上、下午各1次,每次6 min适量步行运动,总疗程8w;对照组仅在入组时和治疗8w结束时进行适量步行运动。两组均在入组前后和治疗8w后同时采集肘静脉血2ml测定血浆TNF-α及STNFR的水平。结果 142例心功能Ⅱ、Ⅲ级的CHF患者在入组后进行限定的运动时间和运动量后发现,运动后较运动前血浆TNF-α及STNFR水平均显著升高(P<0.01),而治疗8w后两组血浆TNF-α及STNFR水平均明显下降(P<0.05);治疗期间运动组较对照组血浆TNF-α及STNFR水平下降明显(P<0.05);治疗8w后运动组的运动距离较对照组增加更明显(P<0.05)。结论 每天适量的步行运动可以有效降低CHF患者血浆炎性细胞因子的含量,有利于CHF患者的康复。
Objective To observe the changes of plasma tumor necrosis factor(TNF) and receptor level of patients with congestive heart failure (CHF) and the effects of quantum satis(qs) of walk and to explore the treatable value of qs walk for the patients with CHF. Methods One hundred and forty - two patients (their cardialfunction were at the stage of Ⅱ or Ⅲ) were randomly divided into movement group(routine plus movement,n = 86) and contol group (routine,n = 56) . Methods of motor - therapy: The patients walked 6 minutes in the morning and afternoon everyday for 8 weeks. Venous blood from the cubital vein was taken before and after enrolment and after 8 week treatment. The levels of plasma TNF -αand STNFR were measured. Results After walk, levels of plasma TNF - αand STNFR significantly increased( P < 0. 01) , which obviously decreased in both groups after 8 week treatment( P < 0.05) , aand were lower in movement group than in control group during treatment(P < 0.05) .After 8 week treatment,walking distance in movement group increased significantly( P < 0.05) . Conclusion Quantum satis of walk one day could effectively reduce the level of plasma TNE and be favourable to recovery of CHF patients.
出处
《临床心身疾病杂志》
CAS
2003年第3期139-141,共3页
Journal of Clinical Psychosomatic Diseases
