摘要
Atg11利用自身众多螺旋结构域作为支架蛋白,主要介导选择性自噬过程中自噬体的形成.选择性自噬可特异性清除损坏的生物大分子和细胞器,在真核生物的胞内物质周转及细胞器质量控制中起重要作用.本文首先介绍了Atg11的结构特点,其次重点介绍了Atg11在3种选择性自噬(细胞质到液泡靶向(Cvt)途径、过氧化物酶体自噬和线粒体自噬)中的作用,最后概括了Atg11的其他功能.本文系统总结了近几年关于Atg11的研究进展,以期为自噬体形成机制研究及Atg11在自噬体形成过程中的功能研究提供参考.
Atg11,as scaffold proteins,mainly mediated the formation of autophagosome in selective autophagy through its many helical domains.Selective autophagy could specifically remove damaged biomolecules and organelles and played an important role in the intracellular material turnover of eukaryotes.Firstly,the structural features of Atg11 were briefly introduced.Secondly,the roles of Atg11 in three kinds of selective autophagy including Cvt pathway,peroxidase autophagy and mitochondrial autophagy were introduced.Finally,the other features of Atg11 were briefly summarized.This review systematically summarized the research progress of Atg11 in recent years,so as to provide references for the formation of autophagosomes and the function of Atg11 in this process.
作者
单友田
顾泽玮
孔冰
阎明芳
王莹莹
陈怡然
景红娟
SHAN You-Tian;GU Ze-Wei;KONG Zhen;ZHOU Ye;LI Bing;YAN Ming-Fang;WANG Ying-Ying;CHEN Yi-Ran;JING Hong-Juan(College of Biological Engineering,Henan University of Technology,Zhengzhou450001,China;National Key Laboratory of Wheat and Maize Crop Science,Zhengzhou450001,China)
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2019年第8期796-803,共8页
Progress In Biochemistry and Biophysics
基金
河南省科技厅自然科学项目(162300410175)
河南工业大学小麦和玉米深加工国家工程实验室项目(NL2016011)
河南工业大学“省属高校基本科研业务费专项资金”(2016QNJH20)资助项目~~
