摘要
目的 比较不同疗程的抗甲状腺药物 (ATD)治疗Graves病的缓解率 ,以探讨药物治疗Graves病的最佳疗程。方法 经确诊的Graves病 192例随机分为三组 ,即疗程 12个月组 ,2 4个月组 ,3 6个月组。分别用他巴唑 3 0mg/日 ,2～ 3个月后逐渐减量至半年减为维持量 ,并均加用左旋甲状腺素 5 0 μg/日 ,直至各疗程结束并随访 2年统计其复发率。 结果 停药后随访 2年内 3组复发率分别为 69%、3 8.2 %和 2 1.2 %,3组间比较差异均有显著性 (P均 <0 .0 1) ,TSAb水平在Ⅱ、Ⅲ组均较Ⅰ组显著降低 (P <0 .0 5 ) ,但Ⅱ、Ⅲ组之间差异无显著性。结论 延长ATD治疗时间可明显提高Graves病的缓解率 ,以 3
Objective To compare the effect of different duration of antithyroid durg(ATD)on the remission rate.In order to investigate the optimal regimen of ATD therapy on the Graves disease.Methods 192 patients were divided randomly into three groups (group 1 for 12 months,group Ⅲ for 24 months,group Ⅲ for 36 months).All patients received carbimazole 30mg daily for 2～3months,following it reduced doses of maintain after 6 months and plus L T4 50 μg daily for treatment duration of in three groups.To observe relapse rate after ATD treatment within the provide of two years in groups each.Results The relapse rate were 69%,38.2 %,and 21.2% within the provide of two years in groups each respectively.There was significant difference in three groups( P <0.01).Levels of TSAb also significant difference in groups Ⅰand groups Ⅱ,Ⅲ,but did not differ between the groupsⅡand Ⅲ.Conclusion prolonging ATD treatment significantly improves the remission rate in GD.The optimal duration of treatment for Graves disease is 3 years.
出处
《临床内科杂志》
CAS
北大核心
2003年第8期419-420,共2页
Journal of Clinical Internal Medicine
基金
广东省卫生厅医学科研资助课题 (A1 9960 1 95)
