摘要
以 3,5 -二甲氧基苯甲酸为原料 ,经还原、溴代后 ,与亚磷酸三乙酯反应成磷酸 3,5 -二甲氧基苄酯 ,再与茴香醛进行 Wittig- Horner反应后脱去酚羟基的保护基得到白藜芦醇。总收率 35 %。
Resveratrol was synthesized from 3,5-dimethoxybenzoic acid by reduction with LiAlH 4, side chain bromination with 40% hydrobromic acid, and reaction with triethylphosphite to give diethyl-(3,5-dimethoxybenzyl)phosphonate which was condensed with anisaldehyde to give 3,5,4′-trimethoxystilbene and then deprotection with BBr 3/CH 2Cl 2. The overall yield was 35%.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2003年第9期428-429,共2页
Chinese Journal of Pharmaceuticals
基金
浙江省卫生厅重点项目 (2 0 0 2 ZD0 0 1)
关键词
白藜芦醇
合成
resveratrol
synthesis
