摘要
目的探讨石杉碱甲对老年男性血管性痴呆(VD)患者雌激素水平和认知功能的影响。方法选取2012年2月—2013年12月新乡医学院第二附属医院收治的男性VD患者120例,比较经石杉碱甲治疗前后的血清雌二醇(E2)水平、简明精神量表(MMSE)评分和P300潜伏期及波幅,分析E2水平与MMSE和P300的相关性。结果治疗后,VD患者的MMSE评分高于治疗前、P300潜伏期短于治疗前,差异有统计学意义(P<0.05),P300波幅和血清E2水平比较,差异无统计学意义(P>0.05)。治疗前,血清E2水平与MMSE评分呈负相关(r=-0.284,P<0.05),和P300潜伏期呈正相关(r=0.238,P<0.05)。结论石杉碱甲可改善老年男性VD患者的认知功能,但不影响其雌激素水平。
Objective To investigate the effect of huperzine A for estrogen and cognitive function in senile male patients with vascular dementia( VD). Methods A total of 120 patients with senile male VD were selected from February 2012 to December 2013 in Henan Normal University Hospital of Medicine,before and after treatment,the levels of serum estradiol( E2),brief psychiatric rating scale( MMSE) score,incubation and amplitude P300 were compared,the correlation between E2 levels and MMSE and P300 were analyzed. Results After treatment,the MMSE score was higher than before treatment,incubation of P300 was shorter than before treatment( P < 0. 05),amplitude of P300 and the level of serum E2 showed no significant differences before and after trteatment( P > 0. 05). Before treatment,the level of serum E2 was negatively correlated with MMSE score( r =- 0. 284,P < 0. 05),the level of serum E2 was negatively correlated with incubation of P300( r = 0. 238,P< 0. 05). Conclusion Huperzine A can improve the cognitive function of senile male patients with VD,but does not affect the estrogen level.
出处
《临床合理用药杂志》
2016年第21期6-8,共3页
Chinese Journal of Clinical Rational Drug Use
基金
河南省教育厅科技攻关项目(12A320014)
