摘要
【目的】验证具有清热燥湿、健脾益气、理气活血作用的中药制剂肠炎清(主要由黄连、黄芪、蒲黄、白芨、元胡等中药组成)对溃疡性结肠炎的治疗效果并探讨其疗效机制。【方法】以葡聚糖硫酸钠(DSS)饮水法复制结肠炎小鼠模型,观察该药对结肠炎小鼠疾病活动指数(DAI)和肠组织髓过氧化物酶(MRO)活性的影响。【结果】肠炎清可降低DAI和MPO活性,与柳氮磺胺吡啶(SASP)疗效相当。【结论】肠炎清对DSS结肠炎有较好的治疗效果,降低MPO的活性可能是其疗效机制之一。
[Objective] To observe the effects of Changyanqing, a Chinese prescription with the actions of regulating qi and activating blood, strengthening spleen-qi and clearing away heat, on ulcerative colitis (UC) and to explore its therapeutic mechanism . [ Methods ] Forty mice were randomized into Changyanqing group ( Group A ), salicylazosulfapyridine group (Group B), Changyanqing and salicylazosulfapyridine (Group C) and model group (Group D). Mouse models with UC were induced by dextran sulfate sodium (DSS). Effects of Changyanqing on disease activity index (DAI) and intestinal myeloperoxidase (MPO) content were observed. [Results] Changyanqing reduced DAI and MPO activity and its effect was similar to that of salicylazosulfapyridine. [ Conclusion ] Changyanqing exerts a better effect in treating DSS-induced UC and one of its therapeutic mechanisms may be related to the reduction of MPO activity.
出处
《广州中医药大学学报》
CAS
2003年第2期140-142,共3页
Journal of Guangzhou University of Traditional Chinese Medicine
关键词
肠炎清
中医药治疗
葡聚糖硫酸钠
结肠炎
实验
小鼠
CHANGYANQING/ther. use
COLITIS, ULCERATIVE/TCD therapy
PEROXIDASE/drug effects
SEVERITY OF ILLNESS INDEX
REGULATING QI
ACTIVATING BLOOD
STRENGTHENING SPLEEN
