摘要
目的 探讨血液B型钠素 (BNP)快速检测在鉴别由充血性心力衰竭 (CHF)所致和肺源性所致急性呼吸困难患者的价值。方法 对就诊的呼吸困难患者 ,用荧光免疫干片法定量快速 (15min)检测全血中的BNP含量 ,并与随后进行的超声心动图、胸部X线等常规检查结果作比较。结果 37例CHFBNP含量为 (72 0 .2 4±4 14 .2 3)ng/L ,BNP >10 0ng/L阳性检出率为 94 .5 9% (35 / 37) ;超声心动图、胸部X线CHF阳性检出率分别为70 .2 7% (2 6 / 35 )、6 4 .86 % (2 4 / 35 ) ,与BNP相比 ,差异均有显著性 (χ2 检验P <0 .0 1)。 5 8例肺源性呼吸困难者的BNP含量为 (36 .81± 4 7.19)ng/L ,BNP >10 0ng/L的假阳性率为 5 .17% (3/ 5 8) ,超声心动图、胸部X线假阳性率均为 3.4 5 % (2 / 5 8)。BNP在两组中的含量有明显差异 (t=9.995 ,P <0 .0 1)。结论 在急诊环境中 。
Objective To investigate whether the patient with acute dyspnea is caused by congestive heart failure(CHF)or pulmonary origin and discuss the clinical value of identification of both diseases using rapid test of B type natriuretic peptide(BNP) in emergency call. Methods The level of BNP in whole blood of the patients with acute respiratory failure was detected by fluorescence immunoassay(15 min) and compared with the results of the following echocardiogram and chest x\|ray. Results The level of BNP in the 37 CHF patients was (720.24±414.23) ng/L. The positive percentage while BNP>100 ng/L was 94.59% (35 out of 37); the positive rates of echocardiogram and chest x\|ray were 70.27%(26 out of 35) and 64.86% (24 out of 35) respectively. There were significant difference in the positive rates of BNP, echocardiogram and chest x\|ray .The level of BNP in the 58 cases with respiratory failure caused by lung was (36.81±47.19) ng/L. The false positive percentage was 5.17% (3 out of 58) while BNP>100 ng/L. The false postive rate was 3.45%(2 out of 58) for both echocardiogram and chest x\|ray. The level of BNP had significant difference between CHF group and the group with lung disease( t =9.995, P <0.01). Conclusions Rapid test of blood BNP is of great importance in diagnosing whether the acute respiratory failure is caused by CHF or pulmonary origin in emergency call.
出处
《上海医学检验杂志》
北大核心
2003年第3期139-141,共3页
Shanghai Journal of Medical Laboratory Sciences
