摘要
目的 研究枳对大鼠食欲的影响。方法 选用SD大鼠 ,禁食 12h后 ,灌胃或腹腔注射枳乙醇提取物水溶液 ;30min后 ,定量给予饲料 ,定时称量剩余食物量并计算大鼠摄食量 ;分别以饮用水或生理氯化钠溶液为空白对照 ,盐酸芬氟拉明为阳性对照 ,计算摄食抑制率。结果 灌胃给予 2 5 0或 12 5mg·kg-1枳乙醇提取物水溶液后 1h的摄食抑制率分别为 :87.6 5± 7.86 ,77.71± 13.0 3;腹腔注射给予 2 5 0或 12 5mg·kg-1枳乙醇提取物水溶液后 1h的摄食抑制率分别为 :98.78± 11.6 2和87.0 7± 15 .0 6 ;灌胃和腹腔注射给予盐酸芬氟拉明后 1h的摄食抑制率分别为 :10 0 .0± 0 .0和 93.0 1± 7.2 9。
Aim To investigate the anorectic effect of alcohol-extract from Hovenia dulcis Thurb (HDT) in rats.Methods The health SD rats were used to evaluate the anorectic effect of alcohol-extract from HDT.The rats subject to fasting for 12 hours,the testing drugs or positive control agents were given by oral and ip injection.After half an hour,the rats were allowed free to feed.The amount of food consumed in 1,2,3,11.5 hours period was weighted.Result HDT showed significant anorectic effect on rats both by oral and by ip injection.After 1 hour,the inhibitive rates are 87.65±7.86,77.71±13.03(250mg·kg -1 or 125mg·kg -1 by oral),98.78±11.62 and 87.07±15.06(250mg·kg -1 or 125mg·kg -1 by ip injection) respectively.Conclusion The results show that alcohol-extract from HDT have significant anorectic effect on rats.
出处
《解放军药学学报》
CAS
2003年第2期114-116,共3页
Pharmaceutical Journal of Chinese People's Liberation Army
