摘要
目的:回顾性分析了不同治疗方案对老年急性髓系白血病(AML)预后的影响。方法:91例老年AML分别采用了标准剂量化疗联合中医治疗、低剂量化疗联合中医治疗、单一中药治疗3组治疗方法对总体生存期(OS)的影响。结果:标准剂量化疗组对OS的影响明显优于低剂量化疗组、单一中药组;标准剂量组、低剂量组治疗过程中均未出现治疗相关死亡病例。但对于年龄> 70岁、ECOG≥2、伴随疾病≥3的患者单一中药组与标准剂量组对OS的影响相似,并明显优于低剂量组。结论:通过对老年AML治疗前评估进行分层,对于年龄> 70岁、ECOG≥2、伴随疾病≥3的老年AML患者单一中药治疗可以取得较好的总体生存。
Objective:To retrospectively analyze the effects of different treatment regimens on the prognosis of eldly acute myeloid leukemia(AML).Methods:A total of 91 elderly AML were treated with standard dose chemotherapy group combined with traditional Chinese medicine,low dose chemotherapy group combined with traditional Chinese medicine,single Chinese medicine treatment group and we analyzed three different groups overall survival(OS).Results:The effect of standard dose chemotherapy group on OS was significantly better than that of low dose chemotherapy group and single Chinese medicine group.There were no treatment-related death cases in standard dose group and low dose group.However,for patients with ECOG≥2 or age>70 or accompanying disease≥3,the effect of single traditional Chinese medicine group on OS was similar to that of standard dose group and was significantly better than that of low dose group.Conclusion:By stratifying the pre-treatment evaluation of AML patients with the age>70 or ECOG≥2 or accompanying disease≥3,the single traditional Chinese medicine can achieve better overall survival.
作者
李巍
王兴丽
张伟锋
刘倩
杨曦
何敬
赵磊
郭江水
房丽君
史哲新
LI Wei;WANG Xingli;ZHANG Weifeng;LIU Qian;YANG Xi;HE Jing;ZHAO Lei;GUO Jiangshui;FANG Lijun;SHI Zhexin(Department of Hematology,The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300380,China)
出处
《辽宁中医杂志》
CAS
2019年第8期1687-1689,共3页
Liaoning Journal of Traditional Chinese Medicine
基金
国家自然科学基金项目(81803918)
关键词
老年
白血病
中医治疗
预后
分层
elderly
leukemia
traditional Chinese medicine treatment
prognosis
stratification
