摘要
Nimesulide(NIM) was administered by gavage to Sprague-Dawley(SD) rats from day 6 to day 15 of getation,at level of 15,30 and 100mg·kg^-1·d^-1.Maternal weight gain was depressed,and the incidences of fetal absorption and lethal fetal were couned in all groups receiving NIM.Malformation of internal organs,appearance of fetuses and retardation of fetal development were not oberved.NIM had little effect on skeletal development,except increasing width of fontanel at high dose(100mg·kg^-1).NIM produced low levels of embryotoxicity and fetotoxicity.But no teratogenic effects of NIM were observed in SD rats.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
2002年第6期428-428,共1页
Chinese Journal of Pharmacology and Toxicology
