摘要
建立了以Fe(Ⅲ)为氧化剂分光光度法测定盐酸氯丙嗪的方法。在盐酸介质中,Fe(Ⅲ)将盐酸氯丙嗪氧化形成一种红色化合物,该化合物的最大吸收波长位于525 nm,其摩尔吸光系数ε=1.05×104 L/(mol·cm)。盐酸氯丙嗪的质量浓度在0~20.0 mg/L范围内与体系的吸光度呈良好的线性关系,线性相关系数r=0.999 2,加标回收率为94.0%~100.4%,测定结果的相对标准偏差为0.55%~1.42%(n=6)。该法灵敏度较高、选择性及重现性良好,可用于药品和血清中盐酸氯丙嗪的测定。
Spectrophotometry was established for the determination of chlorpromazine hydrochloride with Fe( Ⅲ) as oxidizing agent. In the medium of hydrochloric acid,chlorpromazine hydrochloride was oxidied by Fe( Ⅲ) to form a red compound,the maximum absorption wavelength of the compound was 525 nm,the molar absorptivity was 1.05×104 L/(mol · cm). The concentration of chlorpromazine hydrochloride was linear with absorbance in the range of 0–20.0 mg/L, and the correlation coeffi cient was 0.999 2. The recovery rate was 94.0%–100.4%,the relative standard deviation of detection results ranged from 0.55% to 1.42%(n=6). The method had high sensitivity,good selectivity and reproducibility,it can be used for the determination of chlorpromazine hydrochloride in drug and serum.
出处
《化学分析计量》
CAS
2015年第3期59-61,共3页
Chemical Analysis And Meterage
