摘要
目的 :探讨酮替芬联合黄芪颗粒治疗小儿咳嗽变异性哮喘的临床疗效。方法 :选择2012年5月~2014年6月我院儿科收治的咳嗽变异性哮喘患儿120例,将其随机分为观察组和对照组,每组60例,对照组给予酮替芬治疗,观察组在对照组基础上加用黄芪颗粒,两组均治疗两个月,比较两组临床疗效、治疗前后免疫功能变化以及不良反应。结果 :观察组治疗总有效率为93.33%,对照组治疗总有效率为80.00%,两组比较,差异具有统计学意义;观察组治疗后Ig A较治疗前显著升高,Ig E较治疗前显著降低;而对照组治疗前后各体液免疫指标变化均无差异;观察组治疗后CD4+、CD4+/CD8+较治疗前显著升高,而治疗前后CD8+水平无变化;对照组各细胞免疫指标治疗前后均无变化;观察组不良反应发生率3.33%,对照组不良反应发生率13.33%,两组不良反应发生率比较,差异具有统计学意义。结论 :酮替芬联合黄芪颗粒治疗小儿咳嗽变异性哮喘的临床疗效显著,且能够显著改善患儿的机体免疫功能,减少不良反应的发生率,值得临床推广运用。
Objective To investigate the clinical efficacy of ketotifen combined with Astragalus granule in the treatment of children with cough variant asthma. Methods select 2012 May^2014 year in June my courtyard department of pediatrics were treated with cough variant asthma in 120 cases, randomly divided them into observation group and control group, 60 cases in each group, the control group was given ketotifen treatment, the observation group in the control group based on the use of Astragalus granule, two groups were treated for two months, the changes of immune function before and after treatment of clinical efficacy of two groups were compared, and the adverse reaction. Results in the observation group the total effective rate was 93.33%, the control group total effective rate was 80%, two groups, with statistically significant difference; the patients in the observation group Ig A significantly increased, Ig E decreased significantly; and the humoral immune indicators of changes in treatment group there was no difference before and after the treatment; the observation group after treatment, CD4+, CD4+/CD8+were significantly increased, and CD8+ level had no change before and after treatment; the control group before and after the treatment showed no changes of cell immune index; adverse reaction in observation group was 3.33%, in control group, the adverse reaction rate of 13.33%, the occurrence of the two group of adverse reaction rate compared with statistically significant difference.
出处
《晓庄学院学报（医学版）》
2015年第5期101-103,共3页
Journal of Hunan Normal University(Medical Sciences)
关键词
酮替芬
黄芪颗粒
小儿咳嗽变异性哮喘
ketotifen
astragalus particles
children with cough variant asthma
