摘要
目的 :观察和分析血清β-人绒毛膜促性腺激素(β-HCG)及孕酮检测对于先兆流产的临床应用价值。方法 :选取行孕期检查的早期妊娠孕妇150例为研究对象,根据患者临床特点和妊娠结局不同将患者分为三组,其中A组患者50例为正常妊娠孕妇,B组患者42例为先兆流产孕妇,C组患者52例为难免流产孕妇,观察比较三组患者入选时孕酮和血清β-HCG水平差异,通过ROC曲线分析对数据进行灵敏度与特异度分析,确定单一检测和联合检测的临界值。结果 :与正常妊娠的A组比较,B组与C组孕酮及血清β-HCG水平均低于A组,差异有统计学意义。联合检测AUC值高于孕酮与β-HCG单项检测AUC值,联合检测孕酮取值孕酮取值20.34ng/m L,β-HCG取值12814.3m IU/m L时最大Youden指数为0.83,灵敏度为95.3%,特异度为87.6%。结论 :较低的血清孕酮和β-HCG水平可提示先兆流产孕妇不良妊娠结局发生风险的升高,联合检测此两项指标可提高预测不良妊娠结局的特异度,有助于提高预测的准确性。
Objective chorionic gonadotropin(β-HCG) and progesterone detect human observation and analysis of serum β-clinical value for threatened abortion. Methods Bank of early pregnancy prenatal 150 cases of pregnant women for the study, based on clinical characteristics and pregnancy outcomes in patients with different patients were divided into three groups of 50 patients in group A normal pregnant women, 42 patients in group B for threatened abortion pregnant women, 52 patients in group C was inevitable abortion in pregnant women, when observed and compared three groups of patients enrolled in serum progesterone and β-HCG level differences by ROC curve analysis of the sensitivity and specificity of the data analysis, testing and joint detection of a single critical value. Results Compared with normal pregnancy group A and group B and group C serum β-HCG and progesterone levels were lower than the A group, the difference was statistically significant. Combined detection of progesterone and AUC values above detection of β-HCG individual AUC value, the value of combined detection of progesterone progesterone values 20.34ng/m L, β-HCG values 12814.3m IU / m L maximum Youden index was 0.83, sensitivity 95.3%, the specificity was 87.6%. Conclusion The low serum progesterone and β-HCG levels may indicate poor women with threatened abortion increases the risk of pregnancy outcomes, combined detection of these two indicators can improve the prediction of adverse pregnancy outcomes specificity, help improve forecast accuracy sex.
出处
《晓庄学院学报（医学版）》
2015年第4期49-51,共3页
Journal of Hunan Normal University(Medical Sciences)
关键词
先兆流产
孕酮
Β-人绒毛膜促性腺激素
妊娠结局
threatened abortion
progesterone
human chorionic gonadotropin
pregnancy outcome
