摘要
目的探讨检测血清超敏C反应蛋白水平(hs-CRP)在非小细胞肺癌患者中的临床表达意义。方法选取2019年10月至2020年10月我院非小细胞肺癌患者78例为非小细胞肺癌组,1:1配比选取肺良性疾病患者78例为良性组,健康体检者78例为健康对照组。对比三组血清hs-CRP水平、非小细胞肺癌组不同分期血清hs-CRP水平、hs-CRP水平和病情进展关系、hs-CRP水平和远处转移、肿瘤大小关系及手术前后hs-CRP阳性率。结果非小细胞肺癌组血清hs-CRP较良性组、健康对照组高(P<0.05);Ⅳ期非小细胞肺癌患者血清hs-CRP水平较Ⅰ期、Ⅱ期、Ⅲ期高(P<0.05);高hs-CRP水平组疾病控制率60.53%(23/38)较低hs-CRP水平组87.50%(35/40)低(P<0.05);高hs-CRP水平组远处转移68.42%(26/38)较低hs-CRP水平组30.00%(12/40)高(P<0.05);手术后hs-CRP阳性率29.49%(23/78)较手术前57.69%(45/78)低(P<0.05)。结论hs-CRP在非小细胞肺癌患者中表达水平较高,可据此判断疾病控制情况,评估远处转移情况,并能评估手术治疗效果。
Objective To investigate the clinical significance of detecting serum hypersensitive C-reactive protein level(hs-CRP)in patients with non-small cell lung cancer.Methods 78 patients with non-small cell lung cancer(NSCLC)in our hospital from October 2019 to October 2020 were selected as the NSCLC group,78 patients with benign lung disease(1:1 ratio)were selected as the benign group,and 78 healthy subjects were selected as the healthy control group.Serum hs-CRP level of the three groups,serum hs-CRP level of the NSCLC group at different stages,the relationship between hs-CRP level and disease progression,the relationship between hs-CRP level and distant metastasis,tumor size,and the positive rate of hs-CRP before and after surgery were compared.Results Serum hs-CRP of NSCLC group was higher than that of benign group and healthy control group(P<0.05).The serum hs-CRP level of stageⅣNSCLC patients was higher than that of stageⅠ,ⅡandⅢpatients(P<0.05).The disease control rate of the high hs-CRP level group was 60.53%(23/38)lower than that of the low hs-CRP level group(87.50%,35/40).High hs-CRP level group had 68.42%(26/38)higher distant metastasis than low hs-CRP level group(30.00%(12/40),(P<0.05).The positive rate of hs-CRP after surgery was 29.49%(23/78)lower than that before surgery 57.69%(45/78),(P<0.05).Conclusion The expression level of hs-CRP is high in patients with NSCLC,which can be used to judge the disease control situation,evaluate whether the chest lesions are measurable,the distant metastasis and the tumor diameter,and evaluate the effect of surgical treatment.
作者
陈玉洁
CHEN Yu-jie(Xinyang People's Hospital,Xinyang 464000,Henan Province,China)
出处
《罕少疾病杂志》
2025年第4期47-49,共3页
Journal of Rare and Uncommon Diseases
关键词
非小细胞肺癌
血清超敏C反应蛋白
临床表达意义
Non-small Cell Lung Cancer
Serum Hypersensitive C-reactive Protein
Clinical Expression Significance
