摘要
目的:探讨维生素B_(6)辅助治疗,对癫痫患者发作次数、发作持续时间及生活质量的影响。方法:选取2023年6月—2024年6月在本院神经内科就诊的50例癫痫患者为研究对象,将50例患者随机分为观察组和对照组各25例,两组患者性别、年龄、病程、发作次数间均无差异(P>0.05),具有可比性。分别于治疗前及治疗3个月后,记录患者癫痫发作次数和每次发作持续时间,以及生活质量评分(采用SF-36生活质量量表),比较两组患者发作次数、持续时间及生活质量的变化及差异。结果:两组患者经临床治疗后,发作次数及发作持续时间均较治疗前降低,且经维生素B_(6)辅助治疗的观察组患者,治疗后癫痫发作次数显著低于对照组[(2.16±1.24)vs(4.42±1.12)次/月],发作持续时间显著短于对照组[(0.98±0.69)vs(3.16±1.05)min](P<0.001)。且治疗后,两组患者躯体健康、躯体角色功能、躯体疼痛、总体健康、精力、社会功能、情绪角色功能及心理健康8个方面均较治疗前改善(P<0.05),且观察组患者,除躯体疼痛外,生活质量其它部分改善情况显著优于对照组(P<0.05)。结论:维生素B_(6)辅助治疗可降低癫痫患者发作次数,缩短发作持续时间,改善患者生活质量。在癫痫的临床治疗上,可在常规抗癫痫药物的基础上辅以维生素B_(6)治疗,可对患者病情产生积极影响。
【Objective】To investigate the effect of vitamin B_(6) adjunctive therapy,on seizure frequency,seizure duration and quality of life in patients with epilepsy.【Method】Totally 50 epilepsy patients attending the neurology department of our hospital from June 2023 to June 2024 were selected for the study,and the 50 patients were randomly divided into 25 patients each in the observation group and the control group,with no differences between the two groups in terms of gender,age,duration of disease,and frequency of onset(P>0.05),which were comparable.The number of seizures and duration of each seizure,as well as the quality of life score(using the SF-36 quality of life scale)were recorded before and after 3 months of treatment,respectively,and the changes and differences in the number of seizures,duration and quality of life between the two groups were compared.【Result】After clinical treatment in both groups,seizure frequency and seizure duration were reduced compared with those before treatment,and patients in the observation group treated with vitamin B_(6) adjuvant therapy had significantly lower seizure frequency[(2.16±1.24)vs(4.42±1.12)times per month]and shorter seizure duration[(0.98±0.69)vs(3.16±1.05)min]than those in the control group(P<0.001).After treatment,patients in both groups improved in eight aspects of somatic health,somatic role function,somatic pain,general health,energy,social function,emotional role function,and psychological health compared with those before treatment(P<0.05),and the observation group showed significant improvement in other parts of quality of life,except for somatic pain,compared to the control group(P<0.05).【Conclusion】Adjuvant treatment with vitamin B_(6) can reduce the frequency of seizures,shorten the duration of seizures,and improve the quality of life of patients with epilepsy.In the clinical treatment of epilepsy,vitamin B_(6) treatment can be supplemented with conventional antiepileptic drugs,which can have a positive impact on the patient's condition.
作者
谢丽华
刘丹丹
魏欣
赵敏
XIE Li-hua;LIU Dan-dan;WEI Xin;ZHAO Min
出处
《中国食物与营养》
2025年第3期87-90,共4页
Food and Nutrition in China
基金
临汾市科技重点研发计划项目(项目编号:2210)。
