摘要
目的:探讨基于Logistic回归分析脑梗死患者发生下肢深静脉血栓危险因素以及预防策略。方法:选取郑州市第九人民医院2023年3月至2024年4月诊治的119例脑梗死患者作为研究对象,分析两组临床资料、治疗情况、合并症的单因素,采用多因素Logistic回归评估患者发生下肢深静脉血栓的危险因素。并比较不同预防方法下肢深静脉血栓(deep vein thrombosis,DVT)发生率。结果:两组患者的性别、是否吸烟比较(P>0.05)。DVT组年龄≥60岁、美国国立卫生研究院卒中量表(national institute of health stroke scale,NIHSS)评分≥16分、卧床时间≥7 d、合并感染例数均高于非DVT组(P<0.05)。DVT组接受介入治疗、脱水剂使用次数≥4次/d例数均高于非DVT组,服用抗凝药物例数低于非DVT组(P<0.05)。DVT组糖尿病、高血压、高脂血症例数均高于非DVT组(P<0.05)。经对筛选出来的患者发生下肢深静脉血栓10个单因素的变量赋值后,经多因素Logistic回归分析,高血压、合并感染、NIHSS评分≥16分、卧床时间≥7 d、服用抗凝药物、脱水剂使用次数≥4次/d为发生下肢深静脉血栓的危险因素(P<0.05)。间歇性气压治疗(intermittent pneumatic compression,IPC)组、低分子肝素(low-molecular-weight heparin,LMWH)组、IPC+LMWH组DVT发生率均低于常规组(P<0.05);IPC+LMWH组DVT发生率均分别低于IPC组、LMWH组(P<0.05);IPC组、LMWH组组间比较(P>0.05)。结论:高血压、合并感染、NIHSS评分≥16分、卧床时间≥7 d、服用抗凝药物、脱水剂使用次数≥4次/d为发生下肢深静脉血栓的危险因素,采用IPC+LMWH预防干预可有效降低DVT的发生率。
Objective:To explore the risk factors for deep vein thrombosis(DVT)in the lower extremities of patients with cerebral infarction and corresponding prevention strategies based on Logistic regression analysis.Methods:119 patients with cerebral infarction diagnosed and treated at Zhengzhou Ninth People's Hospital between March 2023 and April 2024 were studied.Univariate factors including clinical data,treatment status and comorbidities were analyzed.Multivariate Logistic regression was used to assess the risk factors for deep vein thrombosis in the lower extremities.The incidence of deep vein thrombosis was compared among different prevention methods.Results:There were no significant differences in gender and smoking status between the two groups(P>0.05).The DVT group had a higher proportion of patients aged≥60 years,with a National Institute of Health Stroke Scale(NIHSS)score≥16,bedridden for≥7 days,and with complications of infection compared to the non-DVT group(P<0.05).The DVT group also had a higher proportion of patients undergoing interventional therapy and using dehydrating agents≥4 times/day,but a lower proportion of patients taking anticoagulants(P<0.05).The DVT group also had a higher incidence of diabetes,hypertension and hyperlipidemia compared to the non-DVT group(P<0.05).After assigning values to the 10 univariate variables related to deep vein thrombosis in the lower extremities among the screened patients,multivariate Logistic regression analysis was conducted.The results showed that hypertension,co-infection,NIHSS score≥16,bedridden time≥7 days,anticoagulant use and the use of dehydrating agents≥4 times/day were identified as risk factors for DVT in the lower extremities(P<0.05).The incidence of DVT in Intermittent Pneumatic Compression(IPC)group,low-molecular-weight heparin(LMWH)group and IPC+LMWH group was lower than that in conventional group(P<0.05).The incidence of DVT in IPC+LMWH group was also lower than that in IPC group and LMWH group,respectively(P<0.05).There was no significant difference in DVT incidence between IPC group and LMWH group(P>0.05).Conclusion:Hypertension,infection,NIHSS score≥16,bedridden time≥7 days,anticoagulant use and use of dehydrating agents≥4 times/day are risk factors for DVT in the lower extremities.Preventive intervention with IPC+LMWH can effectively reduce the incidence of DVT.
作者
申倩倩
王婧
刘桂
李晓亮
SHEN Qianqian;WANG Jing;LIU Gui;LI Xiaoliang(Ward 2,Neurology Department,Zhengzhou Ninth People's Hospital,Zhengzhou 450000,China)
出处
《黑龙江医药科学》
2025年第3期35-38,共4页
Heilongjiang Medicine and Pharmacy
基金
2020年度河南省医学科技攻关计划联合共建项目
医用臭氧对烧伤感染患者免疫功能及临床疗效研究项目,编号:LHGJ20200700。
关键词
LOGISTIC回归分析
脑梗死
下肢深静脉血栓
危险因素
预防策略
logistic regression analysis
cerebral infarction
deep vein thrombosis in the lower extremities
risk factors
prevention strategies
