摘要
目的探究地西泮联合常规治疗对高热惊厥复发患儿的疗效及对中性粒细胞淋巴细胞比值(NLR)、神经元特异性烯醇化酶(NSE)及降钙素原(PCT)水平的影响。方法参照随机数字表法将2020年3月至2024年2月于江苏省苏北人民医院就诊的96例高热惊厥复发患儿划分为对照组(常规治疗)与实验组(常规治疗+地西泮),各48例。治疗7 d后比较两组临床疗效、症状减退时间、血常规指标、炎症相关指标和血清NSE水平,统计两组不良反应发生情况及疾病复发率。结果治疗后,与对照组比较,实验组的总有效率较高,差异有统计学意义(P<0.05);惊厥停止时间、完全退热时间和神志恢复时间均明显缩短,差异有统计学意义(P<0.05)。治疗后,实验组红细胞计数、白细胞计数、中性粒细胞计数、NLR、PCT水平和NSE水平均低于对照组,差异有统计学意义(P<0.05);淋巴细胞计数、血红蛋白水平均高于对照组,差异有统计学意义(P<0.05)。治疗期间两组不良反应总发生率对比,差异无统计学意义(P>0.05);治疗后2个月实验组发热和惊厥的总复发率低于对照组,差异有统计学意义(P<0.05)。结论地西泮联合常规治疗用于高热惊厥复发患儿可减轻其脑部损伤程度,临床疗效确切。
Objective To explore the curative effect of diazepam combined with routine treatment and its influences on neutrophil lymphocyte ratio(NLR),neuron-specific enolase(NSE)and procalcitonin(PCT)in children with recurrent febrile convulsion.Methods According to the random number table method,96 children with recurrent febrile convulsion at Jiangsu Subei People's Hospital were divided into a control group receiving routine treatment and an experimental group receiving routine treatment plus diazepam between March 2020 and February 2024,with 48 cases in each group.After 7 days of treatment,cthe linical effectiveness,symptom remission time,routine blood indexes,inflammatory indexes,and serum NSE levels were compared between the two groups.The occurrence of adverse reactions and disease recurrence rate were also statistically analyzed.Results After treatment,the total response rate in the experimental group was higher than that in the control group(P<0.05).The disappearance time of convulsions,complete antipyretic time,and consciousness recovery time were significantly shorter than those in the control group(P<0.05).Additionally,levels of red blood cell count,white blood cell count,neutrophil count,NLR,PCT,and NSE in the experimental group were lower than those in the control group(P<0.05),while lymphocyte count and hemoglobin level were higher than those in the control group(P<0.05).During treatment,there was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Two months after treatment,the total recurrence rate of fever and convulsions in the experimental group was lower than that in the control group(P<0.05).Conclusion Diazepam combined with routine treatments can effectively reduce brain injury and has a definite curative effect.
作者
仲苏蕾
王丽
华芸
华梅琴
左安霞
ZHONG Suli;WANG Li;HUA Yun;HUA Meiqin;ZUO Anxia(Pediatrics of Jiangsu Subei People's Hospital Yangzhou,Yangzhou,Jiangsu,China,225001)
出处
《分子诊断与治疗杂志》
2025年第2期247-250,共4页
Journal of Molecular Diagnostics and Therapy
基金
江苏省苏北人民医院管理课题(YYGL202113)。
