摘要
目的分析外周血循环肿瘤细胞(CTC)与宫颈癌临床病理特征的关系及对其复发的评估价值。方法将80例宫颈癌患者,根据患者术后6个月复发情况分为复发组(n=36例)和非复发组(n=44例)。比较外周血CTC与宫颈癌临床病理特征的关系;比较复发组和非复发组的一般资料及CTC表达情况,评估CTC对宫颈癌复发的预测价值。结果不同年龄、绝经情况、病理类型患者的CTC表达比较差异不显著,P>0.05,不同FIGO分期、淋巴结侵犯、淋巴脉管侵犯、组织分化患者的CTC表达比较差异显著,FIGO分期为ⅡB~Ⅳ期、淋巴结侵犯、淋巴脉管侵犯、低分化患者CTC阳性表达率显著高于ⅠA~ⅡA期、无淋巴结侵犯、无淋巴脉管侵犯、中高分化患者(χ^(2)=6.303,P=0.012、χ^(2)=6.515,P=0.011、χ^(2)=4.266,P=0.039、χ^(2)=6.515,P=0.011)。两组年龄、绝经情况、病理类型比较差异不显著,P>0.05,两组FIGO分期、淋巴结侵犯、淋巴脉管侵犯、组织分化情况比较差异显著,P<0.05。复发组CTC阳性表达率(83.33%)显著高于非复发组(54.55%),差异显著(χ^(2)=7.480,P=0.006)。CTC对宫颈癌患者术后复发的预测价值良好,受试者工作特征曲线下AUC为0.896,灵敏度为0.845,特异度为0.870。结论CTC在宫颈癌患者外周血中阳性表达率较高,CTC可能与FIGO分期、淋巴结侵犯、淋巴脉管侵犯、组织分化有关,对其复发有良好的评估价值。
Objective To analyze the relationship between peripheral blood circulating tumor cells(CTCS)and clinicopathological features of cervical cancer and its value in evaluating disease recurrence.Methods 80 patients with cervical cancer were divided into recurrence group(n=36 cases)and non-recurrence group(n=44 cases)according to the recurrence situation 6 months after operation.To compare the relationship between peripheral blood CTC and clinicopathological features of cervical cancer.The general data and the expression of CTC in recurrent and non-recurrent groups were compared to evaluate the predictive value of CTC in cervical cancer recurrence.Results There were no significant differences in CTC expression among patients with different ages,menopausal conditions and pathological types(P>0.05).There were significant differences in CTC expression among patients with different FIGO stages,lymph node invasion,lymphatic vessel invasion and tissue differentiation.FIGO patients withⅡB toⅣstage,lymph node invasion,and lymphatic vessel invasion had a significantly higher CTC-positive expression rate than those withⅠA toⅡA,no lymph node invasion,no lymphatic vessel invasion,and medium-high differentiation(χ^(2)=6.303,P=0.012,χ^(2)=6.515,P=0.011,χ^(2)=4.266,P=0.039,χ^(2)=6.515,P=0.011).There were no significant differences in age,menopause and pathological types between the 2 groups(P>0.05),while there were significant differences in FIGO stage,lymph node invasion,lymphatic vessel invasion and tissue differentiation between the 2 groups(P<0.05).The positive expression rate of CTC in recurrent group(83.33%)was significantly higher than that in non-recurrent group(54.55%),and the difference was significant(χ^(2)=7.480,P=0.006).The predictive value of CTC for postoperative recurrence of cervical cancer patients was good,with AUC of 0.896,sensitivity of 0.845 and specificity of 0.870 under the subject working characteristic curve.Conclusion The positive expression rate of CTC in peripheral blood of patients with cervical cancer is high,and CTC may be related to FIGO stage,lymph node invasion,lymphatic vessel invasion,and tissue differentiation,which has good evaluation value for disease recurrence.
作者
马竹青
王瑞芳
姜陵
马俊贤
MA Zhuqing;WANG Ruifang;JIANG Ling(The First Affiliated Hospital of Henan University of Science and Technology,Luoyang,471003)
出处
《实用癌症杂志》
2025年第3期390-393,共4页
The Practical Journal of Cancer
关键词
循环肿瘤细胞
宫颈癌
临床病理特征
复发
Circulating tumor cells
Cervical cancer
Clinicopathological features
Recrudescence
