摘要
肺纤维化(pulmonary fibrosis,PF)一种间质性肺疾病的末期表现,其病因尚不完全明确。PF涉及复杂的病理过程,包括炎症反应、氧化应激、内质网应激、细胞衰老、上皮-间充质转化等,目前尚无有效治疗方法,患者确诊后生存期短,死亡率高,严重威胁着人类健康。大量研究表明,Wnt/β-catenin信号通路与TGF-β1/Smad信号通路在PF的发生、发展中均发挥重要了作用。本文就Wnt/β-catenin信号通路与TGF-β1/Smad信号通路在PF中的调控作用,以及二者之间的潜在相互作用和串扰作简要综述,以期为PF的临床防治提供理论支撑。
Pulmonary fibrosis(PF)is a late manifestation of interstitial lung disease,and its etiology is not completely clear.PF involves complex pathological processes,including inflammation,oxidative stress,endoplasmic reticulum stress,cell senescence,epithelial-mesenchymal transition,etc.At present,there is no effective treatment for PF.Patients with PF have a short survival time after diagnosis and a high mortality rate,which seriously threatens human health.A large number of studies have shown that Wnt/β-catenin signaling pathway and TGF-β1/Smad signaling pathway play an important role in the development of pulmonary fibrosis.This article briefly reviews the regulatory role of Wnt/β-catenin signaling pathway and TGF-β1/Smad signaling pathway in PF,as well as the potential interaction and crosstalk between them,in order to provide theoretical support for the clinical prevention and treatment of PF.
作者
周云越
陈星彤
杨金彪
杨蕊红
牛雯颖
ZHOU Yunyue;CHEN Xintong;YANG Jinbiao;YANG Ruihong;NIU Wenying(Basic Medical College,Heilongjiang University of Chinese Medicine,Harbin 150040,China)
出处
《海南医科大学学报》
北大核心
2025年第5期387-392,共6页
Journal of Hainan Medical University
基金
国家自然科学基金资助项目(82274405
82074326)。
