摘要
目的探讨血清人附睾蛋白4(HE4)、肺损伤预测(LIPS)评分与败血症相关急性呼吸窘迫综合征(ARDS)和28 d死亡的相关性。方法选取2021年1月至2024年1月该院收治的败血症患者207例,根据是否并发ARDS分为ARDS组(73例)和非ARDS组(134例),并进一步根据28 d生存情况将ARDS组分为死亡组(26例)和存活组(47例)。采用电化学发光法检测HE4水平,计算LIPS评分。利用多因素Logistic回归模型分析ARDS患者死亡的影响因素,采用点二列相关性分析ARDS患者血清HE4、LIPS评分与28 d死亡的相关性,受试者工作特征(ROC)曲线评价血清HE4、LIPS评分诊断败血症相关ARDS及预测28 d死亡的价值。结果与非ARDS组比较,ARDS组血清HE4水平和LIPS评分升高(P<0.05)。败血症相关ARDS的独立危险因素为序贯器官衰竭评估(SOFA)评分增加、血乳酸升高、HE4升高和LIPS评分增加(P<0.05)。73例败血症相关ARDS患者28 d死亡率为35.62%(26/73)。与存活组比较,死亡组血清HE4、LIPS评分升高(P<0.05)。败血症相关ARDS患者血清HE4、LIPS评分与28 d死亡呈正相关(r=0.605、0.579,P<0.05)。血清HE4联合LIPS评分诊断败血症相关ARDS的曲线下面积(AUC)为0.909,大于血清HE4、LIPS评分单独诊断的0.828、0.806(Z=3.360、3.387,P均<0.05);血清HE4联合LIPS评分预测败血症相关ARDS患者28 d死亡的AUC为0.891,大于血清HE4、LIPS评分单独预测的0.808、0.779(Z=2.028、2.017,均P<0.05)。结论血清HE4水平和LIPS评分升高是败血症相关ARDS的独立危险因素,且与患者28 d死亡密切相关,血清HE4联合LIPS评分诊断败血症相关ARDS及预测患者28 d死亡的价值较高。
Objective To investigate the correlation of serum human epididymis protein 4(HE4)and lung injury Prediction(LIPS)score with sepsis-associated acute respiratory distress syndrome(ARDS)and 28 d mortality.Methods A total of 207 patients with sepsis admitted to the hospital from January 2021 to January 2024 were selected.According to the presence or absence of ARDS,the patients were divided into ARDS group(73 cases)and non-ARDS group(134 cases).According to the 28 d survival,the ARDS group was further divided into death group(26 cases)and survival group(47 cases).HE4 level was detected by electrochemiluminescence,and LIPS score was calculated.Multivariate Logistic regression model was used to analyze the influencing factors of death in ARDS patients.Point biserial correlation was used to analyze the correlation between serum HE4,LIPS score and 28 d death in ARDS patients.The receiver operating characteristic(ROC)curve was used to evaluate the value of serum HE4 and LIPS score in the diagnosis of sepsis-associated ARDS and predicting 28 d mortality.Results Compared with non-ARDS group,the serum HE4 level and LIPS score were significantly increased in ARDS group(P<0.05).The independent risk factors for sepsis-associated ARDS were increased SOFA score,increased blood lactic acid,increased HE4 and increased LIPS score(P<0.05).The 28 d mortality of 73 patients with sepsis-associated ARDS was 35.62%(26/73).Compared with the survival group,the serum HE4 and LIPS scores were increased in the death group(P<0.05).Serum HE4 and LIPS scores were positively correlated with 28 d mortality in patients with sepsis-associated ARDS(r=0.605,0.579,P<0.05).The area under the curve(AUC)of serum HE4 combined with LIPS score in the diagnosis of sepsis-associated ARDS was 0.909,which was larger than 0.828 and 0.806 of serum HE4 and LIPS score alone(Z=3.360,3.387,all P<0.05).The AUC of serum HE4 combined with LIPS score in predicting 28 d mortality of patients with sepsis-associated ARDS was 0.891,which was larger than 0.808 and 0.779 of by serum HE4 and LIPS score alone(Z=2.028,2.017,all P<0.05).Conclusion The elevated serum HE4 level and LIPS score are independent risk factors for sepsis-associated ARDS,and are closely related to 28 d mortality.The combination of serum HE4 and LIPS score has a high value in the diagnosis of sepsis-associated ARDS and the prediction of 28 d mortality.
作者
张祎
刘哲
袁晶
李雯
王文静
ZHANG Yi;LIU Zhe;YUAN Jing;LI Wen;WANG Wenjing(Department of Clinical Laboratory,the First Affiliated Hospital of Xi′an Jiaotong University,Xi′an,Shaanxi 710061,China;Department of Surgical Intensive Care,the First Affiliated Hospital of Xi′an Jiaotong University,Xi′an,Shaanxi 710061,China)
出处
《国际检验医学杂志》
2025年第5期589-594,共6页
International Journal of Laboratory Medicine
基金
陕西省自然科学基础研究计划项目(2023-JC-QN-0898)。
关键词
败血症相关急性呼吸窘迫综合征
人附睾蛋白4
肺损伤预测评分
28
d死亡
sepsis-associated acute respiratory distress syndrome
human epididymis protein 4
lung injury prediction score
28 d mortality
