摘要
目的 评估干扰素α-2b阴道泡腾片结合CO_(2)冷冻治疗对宫颈上皮内病变合并HPV感染患者的免疫指标和炎性水平的影响,并探究其在治疗病变中的潜在效果。方法 本研究纳入了2023年1月1日~2024年2月18日石家庄市第三医院收治的124例宫颈上皮内病变合并HPV感染患者,随机分为A组和B组,每组62例。A组仅接受干扰素α-2b阴道泡腾片治疗,而B组在此基础上增加CO_(2)冷冻治疗。采集治疗前后的免疫细胞计数、细胞因子水平、炎性指标和HPV-DNA定量分析数据,评估治疗效果。结果 B组在治疗后的免疫细胞计数(CD4^(+)/CD8^(+))及细胞因子(IFN-γ和TNF-α)水平均有显著提高。此外,炎症标志物(CRP、IL-6和IL-8)的降低以及HPV清除率(67.74%)均优于A组(45.16%),HPV复发率显著降低(6.45%vs 16.12%)。结论 干扰素α-2b结合CO_(2)冷冻治疗能显著改善宫颈上皮内病变合并HPV感染患者的免疫指标和炎性水平,且有效降低HPV的复发率。这表明该联合治疗策略为宫颈癌前病变的管理提供了一种有效的治疗选择。
Objective This study designed to evaluate the impact of interferon α-2b vaginal effervescent tablets in combination with CO_(2) cryotherapy on the immune markers and inflammation levels in patients with CIN and concurrent HPV infection,and to explore its potential effects in disease treatment.Methods A total of 124 patients with CIN and HPV infection,admitted to our hospital from 1st Jan 2023 to 18th Feb 2024,were selected and randomly divided into an observation group(Group B) and a control group(Group A),with 62 patients in each.The control group received only interferon α-2b vaginal effervescent tablets,while the observation group also underwent CO_(2) cryotherapy.The immune cell counts,cytokine levels,inflammation markers,and HPV-DNA quantification were assessed both before and after treatment.Results The observation group showed significant increase in immune cell counts(CD4~+/CD8~+) and cytokine levels(IFN-γ and TNF-α) after the treatment.Moreover,reductions in inflammation markers(CRP,IL-6 and IL-8) and a higher HPV clearance rate(67.74%) compared to the control group(45.16%),with a significantly lower recurrence rate(6.45% vs 16.12%),were observed.Conclusion The combination of interferon α-2b and CO_(2) cryotherapy have significantly increased the immune markers and reduced inflammation levels in patients with CIN and HPV,and effectively reduced the HPV recurrence rate.This combined treatment strategy presents an effective strategy for the management of precancerous cervical lesions.
作者
宁雪朋
何洁
王培
龚俭雪
NING Xuepeng;HE Jie;WANG Pei(Department of Obstetrics and Gynecology,The Third People′s Hospital of Shijiazhuang,Hebei 050000,China)
出处
《医学研究杂志》
2025年第1期111-115,共5页
Journal of Medical Research
基金
河北省石家庄市科技计划项目(231460493)。
