摘要
目的:回顾性分析应用1 064 nm皮秒激光联合氨甲环酸治疗对黄褐斑患者美观满意度及症状的影响。方法:选取2020年1月-2023年2月河北省沧州市妇幼保健院收治的黄褐斑患者75例,依据治疗方法分为对照组(氨甲环酸治疗,37例)和观察组(氨甲环酸+1 064 nm皮秒激光治疗,38例),两组均连续进行治疗6个月。对比两组治疗6个月后临床疗效、美观满意度,不同时间点黄褐斑面积及严重程度(Melasma area severity index,MASI)评分,治疗前、治疗6个月后血清脂质氧化物(Lipid peroxides,LPO)、谷胱甘肽过氧化物酶(Glutathioneperoxidase,GSH-Px)、褪黑素(Melatonin,MSH)、环氧化酶-2(Cyclooxygenase-2,COX-2)水平、黄褐斑生活质量评分(Melasma quality of life scale,MELASQOL)、皮损面积、皮损颜色评分,研究期间不良反应发生情况。结果:治疗6周后,观察组临床总有效率97.37%高于对照组的75.68%(P<0.05)。对照组与观察组结果所示,较治疗前,治疗1~6个月后两组MASI评分、血清LPO、MSH、COX-2水平、MELASQOL、皮损面积、颜色评分均逐渐降低,观察组低于对照组,血清GSH-Px水平则均升高,观察组高于对照组(P<0.05)。治疗后6个月,观察组美观总满意度高于对照组(P<0.05)。两组不良反应总发生率组间比较,差异无统计学意义(P>0.05)。结论:1 064 nm皮秒激光联合氨甲环酸治疗黄褐斑,有助于缓解患者的黄褐斑症状及皮损情况,抑制氧化应激反应,减少色素沉着,进而提升生活质量,疗效显著,患者治疗后美观满意度较高且安全性良好。
Objective To explore the effect of 1 064 nm picosecond laser combined with tranexamic acid on patients' aesthetic satisfaction and symptoms.Methods From January 2020 to February 2023,75 patients with chloasma in Cangzhou Maternal and Child Health Hospital of Hebei Province were selected and divided into the control group (tranexamic acid treatment,37 cases) and the observation group (control group +1 064 nm picosecond laser treatment,38 cases) according to the treatment methods.Both groups were treated continuously for 6 months.The clinical efficacy,aesthetic satisfaction after 6 months of treatment,scores of area and severity of chloasma (MASI) at different time points,levels of serum lipid oxide (LPO),glutathione peroxidase (GSH-Px),melatonin (MSH),cyclooxygenase-2(COX-2) and scores of Melasma quality of life score (MELASQOL),skin lesion area and skin lesion color before treatment and 6 months after treatment,and incidence of adverse reactions during the study period were compared between the control group and the observation group.Results After 6 weeks of treatment,the total clinical effective rate in the observation group was 97.37% higher than that in the control group (75.68%) (P<0.05).The results of the control group and the observation group showed that the MASI score,serum LPO,MSH,COX-2 levels,MELASQOL,lesion area and color score of the two groups decreased gradually after 1-6 months of treatment,while the observation group was lower than the control group,while the serum GSH-Px level increased,while the observation group was higher than the control group (P<0.05).The results of the control group and the observation group showed that the overall satisfaction rate of the latter was higher after 6 months of treatment (P<0.05).The results of the control group and the observation group showed that there was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05).Conclusion 1 064 nm picosecond laser combined with tranexamic acid in the treatment of chloasma was helpful to relieve the symptoms and skin lesions of patients with chloasma,inhibit oxidative stress reaction,reduce pigmentation,and further improve the quality of life.The curative effect was remarkable,and patients had high aesthetic satisfaction and good safety.
作者
庞超
邹春娜
韩海莉
PANG Chao;ZOU Chunna;HAN Haili(Department of Dermatology,Cangzhou Maternal and Child Health Hospital,Cangzhou 061000,Hebei,China)
出处
《中国美容医学》
2025年第3期102-106,共5页
Chinese Journal of Aesthetic Medicine
关键词
黄褐斑
皮秒激光
氨甲环酸
美观满意度
chloasma
picosecond laser
tranexamic acid
aesthetic satisfaction
