摘要
目的探讨氟比洛芬酯、奥施康定联合姑息性放疗在恶性肿瘤骨转移癌性疼痛患者中的应用效果。方法选取2022年6月至2023年6月湖北省十堰市太和医院收治的112例恶性肿瘤骨转移癌性疼痛患者的临床资料,根据治疗方式不同分为A组(奥施康定联合姑息性放疗)和B组(氟比洛芬酯、奥施康定联合姑息性放疗)。比较2组疼痛缓解效果及首次镇痛起效时间、治疗14 d内暴发痛次数、治疗14 d内奥施康定总用量,以及治疗前和治疗14 d后血清5-羟色胺(5-HT)、前列腺素E 2(PGE 2)、Ⅰ型胶原N末端肽(NTx)水平;比较2组治疗期间药物不良反应总发生率。结果B组镇痛有效率(91.94%)高于A组(78.00%),差异有统计学意义(P<0.05);B组首次镇痛起效时间、治疗14 d内暴发痛次数及治疗14 d内奥施康定总用量均少于A组,差异均有统计学意义(P<0.05);2组治疗后血清5-HT、PGE 2、NTx水平均低于治疗前,且B组治疗后血清5-HT、PGE 2、NTx水平均低于A组,差异均有统计学意义(P<0.05);B组药物不良反应总发生率(50.00%)与A组(46.00%)比较,差异无统计学意义(P>0.05)。结论氟比洛芬酯、奥施康定联合姑息性放疗对恶性肿瘤骨转移癌性疼痛患者的缓解效果更优,该治疗方案镇痛起效快,可减少暴发痛次数,改善患者血清指标水平,且治疗安全性较高。
Objective To investigate the effect of flurbiprofen axetil and oxycontin combined with palliative radiotherapy on cancer pain in patients with bone metastasis of malignant tumors.Methods The clinical data of 112 patients with bone metastasis cancer pain from malignant tumors admitted to Shiyan Taihe Hospital in Hubei Province from June 2022 to June 2023 were selected.According to different treatment methods,they were divided into group A(oxycontin combined with palliative radiotherapy)and group B(flurbiprofen axetil,oxycontin combined with palliative radiotherapy).The pain relief effect,the onset time of first analgesia,the frequency of pain outbreaks within 14 days of treatment,the total dosage of endocontin within 14 days of treatment,and the serum levels of 5-hydroxytryptamine(5-HT),prostaglandin E 2(PGE 2),and N-terminal peptide of typeⅠcollagen(NTx)before and after 14 days of treatment were compared between the two groups.The total incidence of adverse drug reactions during treatment was compared between the two groups.Results The effective rate of analgesia in group B(91.94%)was significantly higher than that in group A(78.00%,P<0.05).The onset time of first analgesia,the number of pain outbreaks within 14 days of treatment,and the total consumption of oxycontin within 14 days of treatment in group B were less than those in group A,and the differences were statistically significant(P<0.05).The levels of serum 5-HT,PGE 2 and NTx in the two groups after treatment were lower than those before treatment,and the levels of serum 5-HT,PGE 2 and NTx in group B after treatment were lower than those in group A,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse drug reactions between group B(50.00%)and group A(46.00%,P>0.05).Conclusion Flurbiprofen axetil and oxycontin combined with palliative radiotherapy have better effect on relieving cancer pain in patients with bone metastasis of malignant tumors.This treatment method has a rapid onset of analgesia,can reduce the frequency of pain outbreaks,improve the serum index levels of patients,and has high treatment safety.
作者
李慧芳
胡皓
胡赤丁
LI Huifang;HU Hao;HU Chiding(Department of Oncology,Shiyan Taihe Hospital,Shiyan,Hubei 442099,China;Department of Oncology,Wuhan No.6 Hospital,Wuhan,Hubei 430014,China)
出处
《检验医学与临床》
2025年第5期605-608,613,共5页
Laboratory Medicine and Clinic
基金
湖北省科技计划立项项目(2021CFA855)。
关键词
氟比洛芬酯
奥施康定
姑息性放疗
恶性肿瘤骨转移
癌性疼痛
flurbiprofen axetil
oxycontin
palliative radiotherapy
bone metastasis of malignant tumor
cancer pain
