摘要
目的:探讨细胞焦亡相关蛋白Gasdermin(GSDM)家族在头颈部鳞状细胞癌(squamous cell carcinoma of head and neck,HNSCC)中的表达及临床意义。方法:基于UALCAN等公共数据库分析GSDM蛋白家族在HNSCC中的差异表达及其与HNSCC患者不良预后的相关性,同时明确GSDM蛋白家族与免疫细胞浸润的相关性。结果:与正常组织相比,GSDM蛋白家族在HNSCC组织中的表达显著增加,且其与HNSCC患者更长的总生存期(overall survival,OS)及免疫细胞浸润密切相关;GSDM蛋白家族在HNSCC中的基因功能主要富集在细胞焦亡等;京都基因和基因组数据库(Kyoto Encyclopedia of Genes and Genomes,KEGG)通路主要富集人乳头状瘤病毒感染等;GSDM蛋白家族在HNSCC中有一定突变率。结论:GSDM蛋白家族在HNSCC组织中的表达水平与正常组织有差异,且其表达水平与免疫细胞浸润及肿瘤预后具有相关性,可作为HNSCC预后标志物及基因治疗靶点。
Objective:To investigate the expression of Gasdermin(GSDM)protein family in squamous cell carcinoma of head and neck(HNSCC)and its diagnostic and prognostic value.Methods:Based on UALCAN and other public databases,the differential expression of GSDM protein family in HNSCC and its correlation with poor prognosis of HNSCC patients were analyzed,and the correlation between GSDM protein family and immune cell infiltration was clarified.Results:Compared with normal tissues,GSDM protein family was significantly increased in HNSCC tissues,and it was closely correlated with longer overall survival(OS)and immune cell infiltration in HNSCC patients.The gene function of GSDM protein family in HNSCC was mainly concentrated in pyrodeath.The Kyoto Encyclopedin of Genes and Genomes(KEGG)pathway was mainly rich in human papilloma virus infection.The GSDM protein family had a certain mutation rate in HNSCC.Conclusion:Based on tumor bioinformatics analysis,the expression level of GSDM protein family in HNSCC tissues is different from that in normal tissues,and its expression level is correlated with immune cell inflitration and tumor prognosis,which can be used as a prognostic marker of HNSCC and a target for gene therapy.
作者
刘炜
尚多
武旭
周兴安
苏尼特
德乐黑巴特尔
LIU Wei;SHANG Duo;WU Xu;ZHOU Xing'an;SU Nite;Deleheibateer(Department of Stomatology,the Fourth Affiliated Hospital of Inner Mongolia Medical University(Sinopharm Yiji Hospital),Baotou 014032;Department of Stomatology,Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010000;Department of Oral and Maxillofacial Surgery,Hohhot Stomatological Hospital,Hohhot 010000,China)
出处
《口腔颌面外科杂志》
2025年第1期34-42,共9页
Journal of Oral and Maxillofacial Surgery
基金
内蒙古医科大学联合项目(YKD2023LH032)
内蒙古自治区高等学校科学研究项目(NJZY21634)
内蒙古自治区自然科学基金项目(2024QN08053)。
关键词
头颈部鳞状细胞癌
GSDM蛋白家族
预后
免疫细胞浸润
head and neck squamous cell carcinoma
GSDM protein family
prognosis
immune cell infiltration
