摘要
目的探讨外周血环状RNA_0001449联合ABCD3-Ⅰ评分对TIA发作后脑梗死的预测价值。方法根据TIA后90 d脑梗死发生情况将204例首次诊断为TIA的患者分为脑梗死进展组和无脑梗死组,比较两组的一般临床资料、ABCD3-Ⅰ评分、外周血环状RNA_0001449表达水平的差异。采用Logistic多因素回归模型分析TIA患者发生脑梗死的危险因素,采用ROC曲线分析ABCD3-Ⅰ评分及外周血环状RNA_0001449表达水平对TIA患者发生脑梗死的预测价值。结果脑梗死进展组的空腹血糖水平、ABCD3-Ⅰ评分、外周血环状RNA_0001449表达水平显著高于无脑梗死组(均P<0.05)。Logistic多因素分析显示,ABCD3-Ⅰ评分增加、外周血环状RNA_0001449表达水平增加是TIA患者发生脑梗死的危险因素(OR=1.975,95%CI:1.352~2.883,P<0.001;OR=22.475,95%CI:1.460~345.868,P=0.026)。ROC曲线分析显示,ABCD3-Ⅰ评分及外周血环状RNA_0001449表达水平单独预测TIA患者发生脑梗死的曲线下面积(AUC)分别为0.805及0.840(均P<0.05),联合预测TIA患者发生脑梗死的AUC为0.881(P<0.05)。联合预测的AUC高于ABCD3-Ⅰ评分及外周血环状RNA_0001449表达水平单独预测(Z=4.851,P=0.011;Z=4.236,P=0.018)。结论外周血环状RNA_0001449联合ABCD3-Ⅰ评分对TIA患者发病后90 d发生脑梗死具有预测价值。
Objective To explore the prediction value of peripheral blood circular RNA_0001449 combined with ABCD3-Ⅰscore on cerebral infarction after TIA.Method According to the occurrence of cerebral infarction 90 days after TIA,204 patients diagnosed with TIA for the first time were divided into cerebral infarction progression group and non-cerebral infarction group.The clinical data,ABCD3-Ⅰscore and peripheral blood circular RNA_0001449 expression level of the two groups were compared.The Logistic multivariate regression model analyzed the risk factors of cerebral infarction in TIA patients.ROC curve was used to analyze the predictive value of ABCD3-Ⅰscore and peripheral blood circular RNA_0001449 expression level on cerebral infarction of TIA patients.Results The fasting blood glucose level,ABCD3-Ⅰscore and peripheral blood circular RNA_0001449 expression of cerebral infarction progression group were significantly higher than those of non-cerebral infarction group(all P<0.05).Logistic multivariate regression analysis showed that increased ABCD3-Ⅰscore and increased peripheral blood circular RNA_0001449 expression were risk factors for cerebral infarction of TIA patients(OR=1.975,95%CI:1.352-2.883,P<0.001;OR=22.475,95%CI:1.460-345.868,P=0.026).ROC curve analysis showed that the area under the curve(AUC)of ABCD3-Ⅰscore and peripheral blood RNA_0001449 expression independently predict cerebral infarction of TIA patients were 0.805 and 0.840,respectively(all P<0.05),the AUC of combination prediction was 0.881(P<0.05).The AUC of combination prediction was significantly higher than that of ABCD3-Ⅰscore and peripheral blood RNA_0001449 expression independent prediction(Z=4.851,P=0.011;Z=4.236,P=0.018).Conclusion Peripheral blood circular RNA_0001449 combined with ABCD3-Ⅰscore has predictive value for cerebral infarction 90 d after the onset of TIA.
作者
孙岭岭
孟军鹏
孟林
狄海莉
赵荣健
SUN Lingling;MENG Junpeng;MENG Lin(Department of Neurology,Northwest University First Hospital,Xi'an 710043,China)
出处
《临床神经病学杂志》
2025年第1期28-31,共4页
Journal of Clinical Neurology
