摘要
目的:观察鸦葱疱疹膏外涂联合注射用甲泼尼龙琥珀酸钠治疗耳部带状疱疹(HZO)的临床疗效。方法:选取2021年6月—2023年6月在联勤保障部队第九八八医院及河南省人民医院就诊的100例HZO患者。按随机数字表法分为治疗组及对照组,每组50例。2组均给予注射用甲泼尼龙琥珀酸钠治疗,在此基础上,治疗组外涂鸦葱疱疹膏治疗,对照组则外涂阿昔洛韦软膏治疗。2组均治疗10d。比较2组临床疗效,症状、体征总评分,疼痛程度[视觉模拟评分法(VAS)],红斑减轻、止疱、结痂、脱痂时间,后遗神经痛(PHN)发生率,以及气导听阈值和气-骨导差值。结果:治疗10d后,治疗组总有效率98.00%(49/50),对照组总有效率84.00%(42/50),2组比较,差异有统计学意义(P<0.05)。治疗10d后,2组症状、体征总评分及VAS评分均较治疗前降低,治疗组症状、体征总评分及VAS评分均低于对照组,差异均有统计学意义(P<0.05)。治疗组红斑减轻、止疱、结痂、脱痂时间均短于对照组,差异均有统计学意义(P<0.05)。治疗结束后随访1个月,治疗组无PHN发生,对照组PHN发生率24.00%(12/50),2组比较,差异有统计学意义(P<0.05)。治疗10d后,2组气导听阈值及治疗组气-骨导差值均较治疗前降低,治疗组气导听阈值及气-骨导差值均低于对照组,差异均有统计学意义(P<0.05)。对照组治疗前、治疗10d后气-骨导差值比较,差异无统计学意义(P>0.05)。结论:鸦葱疱疹膏外涂联合注射用甲泼尼龙琥珀酸钠治疗HZO能缓解疼痛等不适症状、减少PHN发生,并缩短病程、提高听力。
Objective:To observe the clinical effect of external application of Scorzonera Herpes Ointment combined with Methylprednisolone Sodium Succinate for Injection on herpes zoster oticus(HZO).Methods:A total of 100 HZO patients were selected from NO.988 Hospital of Joint Logistic Support Force and Henan Provincial People's Hospital from June 2021 to June 2023.They were divided into the treatment group and the control group according to random number table method,with 50 cases in each group.The two groups were treated with Methylprednisolone Sodium Succinate for Injection.On this basis,the treatment group was treated with external application of Scorzonera Herpes Ointment,and the control group was treated with external application of Acyclovir Ointment.Both groups were treated for 10 days.The clinical effects,total scores of symptoms and signs,pain degree by Visual Analogue Scale(VAS),time of erythema reduction,vesiculation,scab formation and scab removal,incidence of post-herpetic neuralgia(PHN),and the threshold of air conduction hearing and air-bone conduction were compared between the two groups.Results:After 10 days of treatment,the total effective rate was 98.00%(49/50)in the treatment group and 84.00%(42/50)in the control group,the difference being significant(P<0.05).After 10 days of treatment,the total scores of symptoms and signs and VAS scores in the two groups were decreased when compared with those before treatment,and the total scores of symptoms and signs and the VAS score in the treatment group were lower than those in the control group,differences being significant(P<0.05).The time of erythema reduction,vesiculation,scab formation and scab removal in the treatment group was respectively shorter than that in the control group,differences being significant(P<0.05).Follow up for one month after treatment,there was no PHN occurrence in the treatment group and the PHN incidence in the control group was 24.00%(12/50),the difference being significant(P<0.05).After 10 days of treatment,the threshold of air conduction hearing in both groups and the air-bone conduction in the treatment group were decreased when compared with those before treatment,and the threshold of air conduction hearing and the air-bone conduction in the treatment group were lower than those in the control group,differences being significant(P<0.05).There was no significant difference in the comparison of air-bone conduction in the control group before treatment and 10 days after treatment(P>0.05).Conclusion:The external application of Scorzonera Herpes Ointment combined with Methylprednisolone Sodium Succinate for Injection can relieve pain,reduce PHN,shorten the disease course and improve hearing in treating HZO.
作者
李谊
王广科
岳玮
张亚戈
胡浩磊
邢培梅
沈德新
LI Yi;WANG Guangke;YUE Wei;ZHANG Yage;HU Haolei;XING Peimei;SHEN Dexin(Department of Otolaryngology,NO.988 Hospital of Joint Logistic Support Force,Zhengzhou Henan 450042,China;Department of Otolaryngology,Henan Provincial People's Hospital,Zhengzhou Henan 450003,China)
出处
《新中医》
2025年第4期56-60,共5页
New Chinese Medicine
基金
河南省医学科技攻关计划联合共建项目(LHGJ20190879)。
关键词
耳部带状疱疹
鸦葱疱疹膏
外涂
注射用甲泼尼龙琥珀酸钠
后遗神经痛
听力
Herpes zoster oticus
Scorzonera Herpes Ointment
External application
Methylprednisolone Sodium Succinate for Injection
Post-herpetic neuralgia
Hearing
