摘要
G蛋白偶联受体(GPCRs)是一类跨膜受体超家族,参与多种信号转导通路,在细胞迁移、代谢等生理过程中发挥重要功能。T淋巴细胞是重要的免疫细胞,参与炎症反应过程并在细胞免疫中发挥重要作用。目前已发现多种GPCRs在T淋巴细胞中表达并参与T淋巴细胞免疫调节过程,本文将对GPCRs在T淋巴细胞免疫调节中的作用进行综述。
G-protein-coupled receptors(GPCRs)are a type of superfamily of transmembrane receptors,involved in multiple signaling pathways,and playing an important role in physiological processes such as cell migration and metabolism.T lymphocytes are important immune cells that participate in the inflammatory process and play an important role cellular immunity.To date,multiple GPCRs have been found to be expressed in T lymphocytes and participate in T cell immunomodulatory processes.This paper reviews the role of GPCRs in T lymphocyte immunomodulation.
作者
常春艳
王艺霖
逄宇
高孟秋
CHANG Chunyan;WANG Yilin;PANG Yu;GAO Mengqiu(Department of Tuberculosis,Beijing Chest Hospital,Capital Medical University,Beijing 101149,China;Department of Bacteriology and Immunology,Beijing Tuberculosis and Thoracic Tumor Research Institute,Beijing 101149,China)
出处
《中国感染控制杂志》
北大核心
2025年第2期273-281,共9页
Chinese Journal of Infection Control
基金
国家重点研发计划项目(2022YFC2302903)。
关键词
G蛋白偶联受体
T淋巴细胞
免疫
结核
G-protein-coupled receptors
T lymphocytes
immunity
tuberculosis
