摘要
目的采用数据挖掘技术,分析宋代官修方书中所收集痹证的遣方用药规律,以期为当代治疗类风湿等相关病症提供参考借鉴。方法从第5版《中华医典》中收集整理数据,采用Excel建立方药数据库,运用中医传承计算平台(V3.0)、SPSS、Gephi等软件,对纳入的处方深度挖掘,分析其高频用药与关联规则等。结果最终纳入方剂304首,涉及中药272味,使用频次≥30的药物达33种,其中以防风、附子、当归为多;所用药物多温-平,味辛或甘、苦,归肝脾经。以解表药与补虚药为多。基于关联规则分析得到的21个关联组合以独活+附子-防风、羚羊角-防风置信度最高。通过聚类分析共计得到3个聚类组合,6个处方。结论宋代官修方书所体现对痹证的治疗,以祛风蠲痹、调气和血、运脾化湿、滋补肝肾为主,配合调和营卫,常用附子、防风、当归、川芎等药,方用大防风汤、五加皮酒方、萆薢丸方、小活络丹等化裁,可供临床参考。
Objective To analyze the medication regularity for the treatment of arthralgia syndrome collected in official medical texts from the Song Dynasty by data mining technique,aiming to provide reference and insights for the treatment of modern diseases like rheumatoid arthritis.Methods Data were collected from the 5th edition of Chinese Med⁃ical Code and organized into a prescription database using Excel.The data were then analyzed using the Traditional Chinese Medicine Inheritance Computing Platform(V3.0),SPSS,and Gephi software to deeply mine the included prescriptions,fo⁃cusing on high-frequency drugs and association rules.Results A total of 304 prescriptions were included,involving 272 drugs,with 33 drugs used no less than 30 times.The most frequently used drugs were Saposhnikoviae Radix,Aconiti Late⁃ralis Radix Praeparata,and Angelicae Sinensis Radix.The drugs were mainly warm or neutral in nature,pungent or sweet and bitter in flavor,and mainly acted on the liver and spleen meridians.The most commonly used drugs were exterior-re⁃lieving and deficiency-tonifying ones.The analysis of association rules revealed the highest confidence combinations,in⁃cluding Angelicae Pubescentis Radix+Aconiti Lateralis Radix Praeparata-Saposhnikoviae Radix and Saigae Tataricae Cornu-Saposhnikoviae Radix.Cluster analysis identified three main clusters and six prescriptions.Conclusion The treatment of arthralgia syndrome in official medical texts in the Song Dynasty primarily focused on expelling wind,allevia⁃ting impediment,regulating qi,harmonizing blood,promoting spleen function,resolving dampness,and nourishing the liver and kidneys,while harmonizing the nutrient and defense.Commonly used herbs included Aconiti Lateralis Radix Praepara⁃ta,Saposhnikoviae Radix,Angelicae Sinensis Radix,and Chuanxiong Rhizoma,with common prescriptions like Dafangfeng Decoction,Wujia Pijiu Formula,Bixie Pills,and Xiaohuoluo Pills with modifications.These findings provide useful refer⁃ences for modern clinical practice.
作者
薛萌萌
张道雨
唐琪
刘新
XUE Meng-meng;ZHANG Dao-yu;TANG Qi;LIU Xin(School of Traditional Chinese Medicine,Xinjiang Medical University,Urumqi Xinjiang 830011)
出处
《世界中西医结合杂志》
2025年第1期46-51,共6页
World Journal of Integrated Traditional and Western Medicine
基金
国家自然科学基金资助项目(81860834)
十四五自治区高等学校重点学科(新教函[2022]112号)。
关键词
宋代方药
痹证
数据挖掘
用药规律
Prescriptions in the Song Dynasty
Arthralgia Syndrome
Data Mining
Medication Rule
