摘要
目的观察桑黄饮片联合化疗对晚期结直肠癌气血两虚证患者的临床疗效及对其免疫功能的影响。方法纳入67例符合标准的患者,最终完成有效病例60例,将其分为治疗组和对照组,每组30例;对照组采用奥沙利铂注射液联合卡培他滨片的化疗方案,治疗组在对照组治疗基础上加服桑黄饮片,两组均进行2个周期的治疗;观察两组患者实体瘤疗效、中医症状评分、中医证候疗效、免疫功能指标[CD4^(+)T细胞、CD8^(+)T细胞、CD4^(+)/CD8^(+)、自然杀伤(natural killer,NK)细胞、干扰素(interferon,IFN)-γ、白细胞介素-2、白细胞介素-4、肿瘤坏死因子(tumor necrosis factor,TNF)-α]以及不良反应发生情况。结果治疗组疾病控制率显著高于对照组(P<0.05);治疗后两组患者各项评分均较治疗前显著减少(P<0.05),其中治疗组乏力评分较对照组减少更显著(P<0.05);治疗组中医证候疗效优于对照组(P<0.05)。与治疗前比较,治疗后治疗组CD4^(+)T细胞、NK细胞、IFN-γ水平均显著升高(P<0.05),TNF-α水平显著降低(P<0.05);且治疗组上述指标升高或降低程度均显著大于对照组(P<0.05)。两组不良反应发生情况比较,差异均无统计学意义(P>0.05)。结论桑黄饮片联合化疗能够增强晚期结直肠癌的疗效,提高CD4^(+)T细胞、NK细胞、IFN-γ水平,抑制TNF-α水平,显著缓解患者临床症状,且安全可靠。
Objective To investigate the clinical effect of Sanghuang Decoction Pieces combined with chemotherapy in the treatment of patients with advanced colorectal cancer with Qi-blood deficiency and its impact on immune function.Methods A total of 67 patients who met the inclusion criteria were included in this study,and finally 60 patients completed the study,who were divided into treatment group and control group,with 30 patients in each group.The patients in the control group received chemotherapy with the regimen of oxaliplatin Injection combined with Capecitabine Tablets,while those in the treatment group were given Sanghuang Decoction Pieces in addition to the treatment in the control group;both groups were treated for two cycles.The two groups were analyzed in terms of the treatment outcome of solid tumor,traditional Chinese medicine(TCM)symptom score,TCM syndrome score,immune function parameters,cytokines[interferon gamma(IFN-γ),interleukin-2(IL-2),interleukin-4(IL-4),and tumor necrosis factor-α(TNF-α)],and adverse reactions.Results The treatment group had a significantly higher disease control rate than the control group(P<0.05).After treatment,both groups had significant reductions in the above scores(P<0.05),and compared with the control group,the treatment group had a significantly greater reduction in the score of weakness(P<0.05).The treatment group had a significantly better TCM treatment outcome than the control group(P<0.05).After treatment,the treatment group had significant increases in CD4^(+)T cells,NK cells,and IFN-γ(P<0.05)and a significant reduction in TNF-α(P<0.05),and compared with the control group,the treatment group had significantly greater changes in these indicators(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion Sanghuang Decoction Pieces combined with chemotherapy can enhance the treatment outcome of advanced colorectal cancer,increase the levels of CD4^(+)T cells and NK cells,promote the expression of IFN-γ,inhibit the expression of TNF-α,and significantly alleviate the clinical symptoms of patients,with good safety and reliability.
作者
陈友谋
汪天明
孙叶晗
马佳
姚星晨
陈刚
李宁
祝永福
CHEN Youmou;WANG Tianming;SUN Yehan;MA Jia;YAO Xingchen;CHEN Gang;LI Ning;ZHU Yongfu(The First Clinical Medical College of Anhui University of Chinese Medicine,Anhui Hefei 230031,China;Anhui University of Chinese Medicine,Anhui Hefei 230012,China;Anhui Senquangu Pharmaceutical Co.,Ltd.,Anhui Lu’an 237300,China;Anhui Medical University,Anhui Hefei 230032,China;The First Affiliated Hospital of Anhui University of Chinese Medicine,Anhui Hefei 230031,China;Hu Guojun Inheritance Talent Cultivation Office,Anhui Hefei 230031,China)
出处
《安徽中医药大学学报》
2025年第1期21-26,共6页
Journal of Anhui University of Chinese Medicine
基金
“桑黄饮片对肿瘤化疗患者免疫调节及联合化疗抗肿瘤的临床研究开发”项目(2021HZ002)
安徽省高校科研项目(2022AH050415)
安徽中医药大学首批优秀传承骨干人才培养计划(安中人〔2022〕26号)。
关键词
桑黄
晚期结直肠癌
化疗
抗肿瘤
免疫调节
Sanghuang
Advanced colorectal cancer
Chemotherapy
Antitumor effect
Immune modulation
