摘要
This letter discusses the research conducted by Abdel-Razeq et al,highlighting a significant association between Helicobacter pylori(H.pylori)infection and me-tabolic dysfunction-associated steatohepatitis(MASH)in individuals with a prior history of H.pylori infection.Using a comprehensive patient database,the study establishes an independent correlation between H.pylori and an elevated risk of MASH,even after adjusting for coexisting conditions such as obesity,type 2 diabetes,and dyslipidemia.Notably,the findings suggest that H.pylori may wo-rsen liver pathology through inflammatory pathways,contributing to hepatic insulin resistance and lipid accumulation.Although the study provides strong evidence for this association,limitations related to diagnostic heterogeneity in-dicate a need for further research to clarify the underlying mechanisms and to explore the potential roles of genetic and microbiome factors in this relationship.
