摘要
背景:腰椎间盘退变病理改变与腰椎骨密度的相关性存在争议。目的:分析中老年男性和绝经后女性腰椎骨密度与腰椎间盘退变之间的相关性。方法:纳入2018-01-01/2019-01-01在郑州大学第一附属医院郑东院区骨科就诊的腰椎间盘退变患者208例,包括64例中老年男性和144例绝经后女性,平均年龄(62.10±7.74)岁,平均体质量指数(24.71±3.50)kg/m~2,采用双能X射线吸收仪测量L_1-L_4骨密度,通过MRI成像评估椎间盘退变程度,通过Spearman相关分析评价腰椎骨密度与腰椎间盘退变的相关性。结果与结论:(1)中老年男性与绝经后女性的腰椎骨密度均随着腰椎节段的降低而增加,中老年男性L_1-L_4骨密度与腰椎平均骨密度均高于绝经后女性(P<0.05);(2)中老年男性与绝经后女性的腰椎间盘退变程度都随着腰段节段的降低而加重,中老年男性和绝经后女性相同节段的腰椎间盘退变等级无显著差异(P>0.05);(3)Spearman相关分析显示,每个节段(L_1-L_4)的腰椎间盘退变等级与相邻椎体骨密度之间的相关性存在性别差异,绝经后女性各节段腰椎间盘退变等级与相邻椎体骨密度呈正相关(P<0.05),椎间盘退变等级与下位椎体骨密度的相关性高于椎间盘退变等级与上位椎体骨密度的相关性;中老年男性各节段椎间盘退变等级与相邻椎体骨密度无相关性(P>0.05);(4)结果表明,绝经后女性腰椎间盘退变等级与邻近椎体骨密度呈正相关,尤其是与相邻下位椎体骨密度相关性更强,但中老年男性腰椎间盘退变等级与邻近椎体骨密度无明显相关性。
BACKGROUND:The relationship between pathological changes of lumbar disc degeneration and lumbar bone mineral density is still controversial.OBJECTIVE:To investigate the relationship between lumbar disc degeneration and lumbar bone mineral density in middle-aged and elderly men and postmenopausal women.METHODS:This study enrolled 208 patients with lumbar disc degeneration,including 64 middle-aged and elderly males and 144 postmenopausal females,with a mean age of(62.10±7.74)years and a mean body mass index of(24.71±3.50)kg/m2,who admitted at the Department of Orthopedics of Zhengdong Hospital,the First Affiliated Hospital of Zhengzhou University from January 1,2018 to January 1,2019.The bone mineral density of L1-L4 was measured using a dual energy X-ray absorptiometry.Magnetic resonance imaging was taken to grade the severity of lumbar disc degeneration in each segment.The correlation between lumbar bone mineral density and lumbar disc degeneration was evaluated by Spearman correlation analysis.RESULTS AND CONCLUSION:The lumbar bone mineral density of both middle-aged and elderly men and postmenopausal women increased with the lowering of lumbar spine segments,and the L1-L4 bone mineral density and the average lumbar bone mineral density of middle-aged and elderly men were higher than those of postmenopausal women(P<0.05).The lumbar intervertebral disc degeneration of both middle-aged and elderly men and postmenopausal women increased with the lowering of lumbar spine segments,and there was no significant difference in the grades of lumbar disc degeneration of the same segments in middle-aged and elderly men and postmenopausal women(P>0.05).Spearman correlation analysis showed that there were sex differences in the correlation between the lumbar disc degeneration grade and the adjacent vertebral bone mineral density in each segment(L1-L4).The lumbar disc degeneration grade of each segment was positively correlated with the adjacent vertebral bone mineral density in postmenopausal women(P<0.05),and the correlation between the disc degeneration grade and the lower vertebral bone mineral density was higher than that between the disc degeneration grade and the upper vertebral bone mineral density.However,there was no correlation between lumbar disc degeneration grade of each segment and the adjacent vertebral bone mineral density in middle-aged and elderly men(P>0.05).To conclude,the grade of lumbar disc degeneration is positively correlated with adjacent vertebral bone mineral density in postmenopausal women and the correlation coefficient of adjacent lower vertebral body is higher,but no significant correlation is found in middle-aged and elderly men.
作者
王润政
付苏
董超
李东哲
王永魁
Wang Runzheng;Fu Su;Dong Chao;Li Dongzhe;Wang Yongkui(Department of Orthopedics,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,Henan Province,China)
出处
《中国组织工程研究》
北大核心
2025年第24期5079-5085,共7页
Chinese Journal of Tissue Engineering Research
基金
国家自然科学基金项目(81802128),项目负责人:王永魁。
关键词
骨密度
椎间盘退变
腰椎间盘退变
改良Pfirrmann分级系统
绝经后女性
中老年男性
腰痛
坐骨神经痛
骨质疏松
bone mineral density
intervertebral disc degeneration
lumbar disc degeneration
modified Pfirrmann grading system
postmenopausal women
middle-aged and elderly men
low back pain
sciatica
osteoporosis
