摘要
超分子纳米药物递送平台因具有性质多样化、药物释放可控及制备简易等特点而备受关注.据报道,富含酚羟基结构的多酚可与不同性质类药物产生非共价相互作用,自组装成超分子纳米系统,从而实现不同路径的药物递送.同时,多酚自身具备抗肿瘤、抗菌、抗氧化、抗炎和保护心脏等功能,这使得基于多酚的递送系统在疾病治疗方面前景广阔.本综合评述概述了多酚型超分子纳米递送系统构建中包括的超分子相互作用力.根据所负载药物的性质(例如疏水性药物、蛋白质、DNA等),分类阐述了不同相互作用力在药物负载中发挥的功能.最后,对当前基于多酚的超分子纳米系统中存在的争议性问题进行了评述总结.本文可为各种新兴的多酚基材料的设计和基础研究提供参考.
Supramolecular drug delivery nanoplatforms have attracted much attention due to their diverse functions,controllable drug-releasing property,and unsophisticated techniques for preparation.Polyphenols with phenolic hydroxyl structure have been reported to easily have non-covalent interactions with different drugs,next selfassembling to be supramolecular nanosystems and successfully delivering drugs through desirable administrations.Moreover,polyphenols per se are generally active in defensing tumor,bacteria,oxidative species,inflammation,and protecting cardiac function,which can broaden the biomedical application scope of polyphenol-based delivery systems.In this review,we comprehensively depict the supramolecular interactions involved in the polyphenol-based supramolecular drug delivery systems,and detailedly explain how the interaction force highly affects the drug loading(e.g.,hydrophobic drugs,proteins,and DNA,etc.).Finally,the controversial issues existing in current polyphenol-based supramolecular nanosystems are summarized and reviewed.This article is expected to shed a new light on the rational designs and fundamental studies of emerging polyphenol-based materials.
作者
严子谅
李蓓
代云路
YAN Ziliang;LI Bei;DAI Yunlu(Faculty of Health Sciences,Ministry of Education Frontiers Science Centre for Precision Oncology,University of Macao,Macao SAR 999078,China)
出处
《高等学校化学学报》
北大核心
2025年第1期14-32,共19页
Chemical Journal of Chinese Universities
基金
国家自然科学基金(批准号:32222090,32171318,32101069)
澳门大学多年度研究项目(批准号:MYRG2022-00011-FHS,MYRG-GRG2023-00013-FHS-UMDF)
澳门特别行政区科学技术发展基金(批准号:0103/2021/A,0002/2021/AKP,0133/2022/A3,0009/2022/AKP,0006/2023/ITP1)
澳门大学教育部精准肿瘤学前沿科学中心项目(批准号:SP2023-00001-FSCPO)资助.
关键词
超分子纳米系统
多酚
药物递送
纳米粒子
Supramolecular nanosystem
Polyphenol
Drug delivery
Nanoparticles
