摘要
目的探究坤泰胶囊联合二甲双胍治疗超重或肥胖多囊卵巢综合征(PCOS)不孕症患者的临床疗效,进一步阐明其机制。方法选取2021年1月到2023年12月在中国人民解放军联勤保障部队第九〇一医院诊治的116例超重或肥胖PCOS不孕症患者作为研究对象,按照随机数字表法将其分为对照组(采用二甲双胍治疗,n=57)和联合组(采用二甲双胍与坤泰胶囊联合治疗,n=59)。两组均连续用药12周。对比两组疗效、血糖、血脂、胰岛素抵抗等指标,子宫内膜容受性变化,卵巢及妊娠情况,晚期糖基化终末产物(AGE)-晚期糖基化终末产物受体(RAGE)信号通路指标及不良反应发生情况。结果联合组治疗有效率(86.44%)高于对照组(70.18%)(P<0.05)。治疗后,两组空腹血糖(FPG)、甘油三酯(TG)、总胆固醇(TC)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、抗米勒管激素(AMH)、雌二醇(E_(2))、黄体生成素(LH)/卵泡刺激素(FSH)、Ⅲ型胶原α1链(COL3A1)、凋亡因子Bcl-2关联X的蛋白(Bax)mRNA指标均降低,B淋巴细胞瘤-2(Bcl-2)mRNA、子宫内膜厚度均升高,且联合组更显著,差异均具有统计学意义(P<0.05)。联合组优势卵泡数多于对照组,卵泡生成时间短于对照组,周期妊娠率高于对照组,差异均具有统计学意义(P<0.05)。结论相比单纯应用二甲双胍,联合坤泰胶囊疗效更显著,其机制可能与调节AGE-RAGE信号通路有关。
Objective To explore the clinical efficacy of Kuntai Capsule combined with metformin in the treatment of overweight or obese patients with polycystic ovary syndrome(PCOS)infertility,and to further clarify its mechanism.Methods A total of 116 overweight or obese PCOS infertility patients treated in the 901st Hospital of the Chinese People's Liberation Army Joint Logistic Support Force from January 2021 to December 2023 were selected as the research objects,and they were divided into control group(treated with metformin,n=57)and combined group(treated with metformin and Kuntai Capsule,n=59)according to the random number table method.Both groups were treated for 12 weeks continuously.The efficacy,blood glucose,blood lipids,insulin resistance and other indicators,endometrial receptivity changes,ovarian and pregnancy conditions,advanced glycation end products(AGE)-receptor for AGE(RAGE)signaling pathway and adverse reactions condition were compared between the two groups.Results The effective rate of the treatment in the combined group(86.44%)was higher than that in the control group(70.18%)(P<0.05).After treatment,fasting plasma glucose(FPG),triglyceride(TG),total cholesterol(TC),fasting insulin(FINS),homeostasis model assessment of insulin resistance(HOMA-IR),body mass index(BMI),anti-Müllerian hormone(AMH),estrodiol(E_(2)),luteinizing hormone/follicle stimulating hormone(LH/FSH),endometrial thickness,Type Ⅲ collagenα1 chain(COL3A1)and apoptosis factor Bcl-2 associated X protein(Bax)mRNA indexes in the two groups all decreased,while B lymphocytic neoplasm-2(Bcl-2)mRNA and endometrial thickness increased,and those in the combined group were more significant,with statistically significant differences(P<0.05).The number of dominant follicles in the combined group was more than that in the control group,the follicle formation time was shorter than that in the control group,and the cycle pregnancy rate was higher than that in the control group,with statistically significant differences(P<0.05).Conclusions Compared with applying metformin alone,Kuntai Capsule combined with metformin is more effective,and its mechanism may be related to the regulation of AGE-RAGE signaling pathway.
作者
程春秀
魏玉业
李玲
崔智慧
CHENG Chunxiu;WEI Yuye;LI Ling;CUI Zhihui(Department of Obstetrics and Gynecology,901st Hospital of the Chinese People's Liberation Army Joint Logistic Support Force,Hefei 230000,Anhui,China;Department of Ultrasound,901st Hospital of the Chinese People's Liberation Army Joint Logistic Support Force,Hefei 230000,Anhui,China)
出处
《中国性科学》
2025年第1期134-138,共5页
Chinese Journal of Human Sexuality
