摘要
目的观察如意金黄散外敷联合抗蝮蛇毒血清对蝮蛇咬伤患者创面愈合及肢体肿胀的影响。方法患者100例以随机数表法分为对照组与研究组各50例。对照组行常规处理和皮下注射抗蝮蛇毒血清,研究组在此基础上予以如意金黄散外敷。比较两组患者疗效、视觉模拟量表(VAS)评分、创面愈合情况、肢体情况、炎症水平[白细胞计数(WBC)、C反应蛋白(CRP)]和凝血功能[凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)]。结果研究组患者总有效率高于对照组(P<0.05)。研究组患者治疗后VAS评分、创口面积均低于对照组(P<0.05);研究组患者创面愈合率高于对照组,平均愈合时间低于对照组(均P<0.05)。研究组患者治疗后患肢周径差值高于对照组,肢体活动障碍评分均低于对照组,且肿胀恢复时间短于对照组(均P<0.05)。研究组患者治疗后WBC、CRP、PT、APTT均低于对照组(均P<0.05)。结论如意金黄散联合抗蝮蛇毒血清用于蝮蛇咬伤患者,可促进创面愈合,加快消除肢体肿胀,减轻疼痛,提升疗效。
Objective:To explore the effect of external application of Ruyi Jinhuang Powder combined with Ag⁃kistrodon halys antivenom on wound healing and limb swelling in patients with Agkistrodon halys bites.Methods:A total of 100 patients with Agkistrodon halys bites admitted were randomly divided into a control group(n=50)and a study group(n=50)using a random number table method.The control group received routine treatment and subcutaneous injection of Agkistrodon halys antivenom,while the study group received external application of Ruyi Jinhuang Powder on this basis.The therapeutic effects,visual analogue scale(VAS)scores,wound healing,limb condition,and inflammation levels[white blood cell count(WBC),C-reactive protein(CRP)],and coagulation func⁃tion[prothrombin time(PT),activated partial thromboplastin time(APTT)]were compared between two groups.Results:The total effective rate of the study group was higher than that of the control group(P<0.05).The VAS score and wound area of the study group after treatment were lower than those of the control group(P<0.05);the wound healing rate of the study group was higher than that of the control group,and the average healing time was shorter than that of the control group(all P<0.05).After treatment,the difference in limb circumference between the study group and the control group was higher,and the scores of limb mobility disorders were lower than those of the control group;the swelling recovery time was shorter in the study group than in the control group(all P<0.05).The levels of WBC,CRP,PT,and APTT in the study group were all lower than the control group after treat⁃ment(all P<0.05).Conclusion:The combination of Ruyi Jinhuang Powder and Agkistrodon halys antivenom can promote wound healing,accelerate the elimination of limb swelling,alleviate pain,and improve therapeutic effects in patients with Agkistrodon halys bites.
作者
叶玲
王竞飞
辛颖
刘霞
于会芳
刘晏宏
Ye Ling;Wang Jingfei;Xin Ying;Liu Xia;Yu Huifang;Liu Yanhong(Meishan Traditional Chinese Medicine Hospital,Sichuan,Meishan 620000,China)
出处
《中国中医急症》
2024年第12期2134-2137,共4页
Journal of Emergency in Traditional Chinese Medicine
基金
眉山市科技指导性计划项目(2023KJ2D151)。
关键词
蝮蛇咬伤
如意金黄散
抗蝮蛇毒血清
创面愈合
肢体肿胀
炎症因子
凝血功能
Agkistrodon halys antivenom
Ruyi Jinhuang Powder
Agkistrodon halys bites
Wound healing
Limb swelling
Inflammatory factors
Coagulation function
