摘要
目的观察ω-3多不饱和脂肪酸(ω-3PUFAs)对重型颅脑损伤(STBI)肠内营养(EN)支持治疗患者血清炎症因子水平及预后的影响。方法2021年1月至2023年12月本院收治的STBI患者共80例按均衡随机化分组分为观察组和对照组,每组40人。观察组和对照组分别在常规EN支持的基础上加入相同热卡的ω-3鱼油脂肪乳和脂肪乳注射液,疗程为14.d。比较两组患者治疗前后营养指标、免疫指标、血清炎症因子水平、格.拉斯哥预后评分(GOS)。结果治疗后观察组炎症因子水.平较治疗前明显降低(P<005),患者治疗后营养指标均有下降,观.察组营养指标较对照组高(P<005),观察组治疗后T细胞亚群水平明显低于对照组(P<005),治疗后患者GOS均有上升,观察组GOS显著高于对照组(P<005)。结论ω-3PUFAs对STBIEN支持治疗患者有助于增强患者抗炎和免疫能力,改善其肠胃功能和预后情况。
Objective To observe the effect of omega-3 polyunsaturated fatty acids(omega-3 PUFAs)on serum inflammatory factor levels and prognosis in patients with severe traumatic brain injury(STBI)undergoing enteral nutrition(EN)support therapy.Methods A total of 80 patients with STBI who were admitted to the hospital from January 2021 to December 2023 were randomly assigned to the observation group and the control group,with 40 patients in each group.On the basis of conventional EN support,the observation group and the control group were treated with the same calorie of omega-3 fish oil fat emulsion and fat emulsion injection,respectively.Both groups were treated for 14 days.The nutritional indicators,immune indicators,serum inflammatory factor levels and Glasgow Outcome Scale(GOS)scores were compared between the groups.Results After treatment,there were significant decreases in inflammatory factor levels in the observation group(P<0.05).After treatment,nutritional indicators decreased,but the indicators in observation group were higher than those in control group(P<0.05).After treatment,the levels of T cell subsets in observation group were significantly lower than those in control group(P<0.05).After treatment,GOS scores increased and observation group had significantly higher scores than control group(P<0.05).Conclusion Applying omega-3 PUFAs in EN support for patients with STBI can help to improve patients’anti-inflammatory and immune ability,improve their gastrointestinal function and prognosis.
作者
李景
冯海旺
周瑞琴
LI Jing;FENG Hai-wang;ZHOU Rui-qin(Department of Critical Care Medicine,Luohe Maternal and Child Health Hospital,Luohe Third People’s Hospital,Luohe 462300,Henan Province,China)
出处
《罕少疾病杂志》
2025年第1期133-135,共3页
Journal of Rare and Uncommon Diseases
关键词
3多不饱.和脂肪酸
重型颅脑损伤
肠内营养支持
血清炎症因子水平
Omega-3 Polyunsaturated Fatty Acids
Severe Traumatic Brain Injury
Enteral Nutrition Support
Serum Inflammatory Factor Levels
