摘要
目的:观察左西孟旦联合膈肌电刺激对困难脱机风险患者的临床疗效。方法:选择2021年12月—2023年12月于赣州市人民医院就诊的困难脱机风险患者92例,采用随机数字表法将其分成常规组(n=46)与观察组(n=46)。常规组接受膈肌电刺激治疗,观察组在常规组的基础上接受左西孟旦治疗。比较两组ICU住院时间、呼吸机使用时长、脱机相关指标、炎症因子及脱机成功率。结果:观察组ICU住院时间、呼吸机使用时长均短于常规组(P<0.05)。治疗前,两组脱机相关指标比较,差异均无统计学意义(P>0.05);治疗48 h后,两组N末端B型利钠肽原(NT-proBNP)水平均降低,且观察组较常规组低,氧合指数均升高,且观察组较常规组高,差异均有统计学意义(P<0.05)。治疗前,两组白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)比较,差异均无统计学意义(P>0.05);两组治疗48 h后的IL-6、TNF-α均降低,观察组均较常规组低(P<0.05)。观察组脱机成功率高于常规组,差异有统计学意义(P<0.05)。结论:左西孟旦联合膈肌电刺激应用于困难脱机风险患者,可缩短ICU住院时间、呼吸机使用时长,减轻炎症反应,调节氧合指数、NT-proBNP水平,提高脱机成功率。
Objective:To observe the clinical efficacy of Levosimendan combined with diaphragmatic electrical stimulation in patients with risk of difficult offline.Method:A total of 92 patients with risk of difficult offline who visited in Ganzhou People's Hospital from December 2021 to December 2023 were selected and divided into conventional group(n=46)and observation group(n=46)by random number table method.The conventional group received diaphragmatic electrical stimulation treatment,and the observation group received Levosimendan treatment on the basis of the conventional group.The length of ICU stay,ventilator use time,offline related indexes,inflammatory factors and offline success rate were compared between the two groups.Result:The length of ICU stay and ventilator use time in observation group were shorter than those in conventional group(P<0.05).Before treatment,there were no significant differences in offline related indexes between the two groups(P>0.05).After 48 hours of treatment,the levels of N-terminal pro-brain natriuretic peptide(NT-proBNP)were decreased in both group,and that in the observation group was lower than that in the conventional group,the oxygenation index were increased in both group,and that in the observation group was higher than that in the conventional group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)between the two groups(P>0.05).After 48 hours of treatment,IL-6 and TNF-αwere decreased in both group,and those in the observation group were lower than those in the conventional group(P<0.05).The offline success rate of observation group was higher than that of conventional group,the difference was statistically significant(P<0.05).Conclusion:The application of Levosimendan combined with diaphragmatic electrical stimulation in patients with risk of difficult offline can shorten the length of ICU stay and ventilator use time,reduce inflammatory response,adjust the oxygenation index and NT-proBNP level,and improve the offline success rate.
作者
关欢
曹猛
方景云
GUAN Huan;CAO Meng;FANG Jingyun(Department of Emergency,Ganzhou People's Hospital,Ganzhou 341000,China;不详)
出处
《中国医学创新》
CAS
2025年第1期35-38,共4页
Medical Innovation of China
关键词
膈肌电刺激
左西孟旦
困难脱机
脱机成功率
Diaphragmatic electrical stimulation
Levosimendan
Difficult offline
Offline success rate
