摘要
目的了解广州某医院甲型、乙型、丙型和戊型肝炎病毒感染特征及流行病学特征,为当地对病毒性肝炎的防控提供参考。方法对2020年1月—2023年12月在广州某医院接受血清HAV-IgM抗体、HBV表面抗原、HCV抗体、HEV-IgG抗体及HEV-IgM抗体检测的门诊、住院患者及体检者的阳性率、年份、性别和年龄进行横断面研究。结果近4年HAV-IgM抗体、HBV表面抗原、HCV抗体、HEV-IgG抗体及HEV-IgM抗体的阳性人数及阳性率依次为40例(0.04%)、28120例(11.16%)、1294例(0.54%)、13773例(15.76%)和426例(0.46%),阳性率最高的为HEV-lgG抗体,阳性数最多的为HBV表面抗原;HEV-lgG抗体阳性数及阳性率有逐年下降趋势;不同年份的HBV和HEV-lgG阳性率比较差异有统计学意义(P<0.05);男性HBV、HCV、HEV-IgG的阳性率均高于女性,HBV、HCV、HEV-IgG的男女阳性率比较差异有统计学意义(P<0.05);HBV表面抗原和HEV-lgG抗体不同年龄段男女感染人数差异有统计学意义(P<0.05);不同年龄段HBV表面抗原、HCV、HEV-IgG阳性率差异有统计学意义(P<0.05)。结论乙型肝炎仍是感染人数最多的病毒性肝炎,其次是戊型肝炎,其高阳性率也应引起广泛关注,此外男性在多种病毒性肝炎中感染均高于女性,应是防控的重点。
Objective To investigate the infection and epidemiological characteristics of hepatitis A,B,C and E viruses in a hospital in Guangzhou,so as to provide insights for local prevention and control of viral hepatitis.Methods A cross-sectional study on the analysis was conducted on the positive rates,years,gender,and ages of outpatients,inpatients,and individuals undergoing physical examinations who underwent serum HAV-IgM antibody,HBV surface antigen,HCV antibody,HEV-IgG antibody,and HEV-IgM antibody detection in a hospital in Guangzhou from January 2020 to December 2023.Results Over the past four years,the positive numbers and rates of HAV-IgM antibody,HBV surface antigen,HCV antibody,HEV-IgG antibody and HEV-IgM antibody were 40 cases(0.04%),28120 cases(11.16%),1294 cases(0.54%),13773 cases(15.76%)and 426 cases(0.46%),respectively.The highest positive rate was observed for HEV-IgG antibody,while the highest number of positive cases was for HBV surface antigen.The positive number and positive rate of HEV-IgG antibody decreased year by year.There was statistically significant difference in the positive rates of HBV and HEV lgG between different years(P<0.05).The positive rates of HBV,HCV and HEV-IgG in males were higher than those in females,there was statistically significant difference in the positive rates of HBV,HCV,and HEV-IgG between males and females(P<0.05).There was statistically significant difference in the number of males and females infections with HBV surface antigen and HEV-IgG antibody in different age groups(P<0.05).There were statistically significant differences in the positive rates of HBV surface antigen,HCV,and HEV-IgG among different age groups(P<0.05).Conclusion Hepatitis B remains the viral hepatitis with the largest number of infections,followed by hepatitis E,and its high positive rate should also be widely concerned.In addition,males are more infected than females in various viral hepatitis,which should be the focus of prevention and control.
作者
黄海燕
赖圣明
任书纬
肖艳红
HUANG Haiyan;LAI Shengming;REN Shuwei;XIAO Yanhong(Department of Clinical Laboratory,the Sixth Affiliated Hospital of Sun Yat-sen University,Guagnzhou 510091,Guangdong,China;Zhongliu Biomedical Innovation Center in Huangpu District,Guagnzhou 510091,Guangdong,China)
出处
《右江医学》
2024年第11期1007-1013,共7页
Chinese Youjiang Medical Journal
基金
国家自然科学基金青年项目(82203703)。
关键词
甲型肝炎
乙型肝炎
丙型肝炎
戊型肝炎
流行病学特征
hepatitis A
hepatitis B
hepatitis C
hepatitis E
epidemiological characteristics
