摘要
目的分析柴芍六君子汤联合茴三硫片治疗慢性胆囊炎对患者腹痛程度、胆囊收缩功能及炎症反应的影响。方法84例开封市第二中医院2022年1月至2024年1月收治的慢性胆囊炎患者随机分为试验组和对照组,各42例。对照组给予茴三硫片治疗,试验组在对照组基础上给予柴芍六君子汤治疗,两组均连续治疗8周,比较两组治疗总有效率,血清炎症因子[血清C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、瘦素(Lep)]水平,胆囊厚度,胆囊收缩率,腹痛程度[视觉模拟评分法(VAS)],及不良反应发生率。结果试验组的治疗总有效率为92.86%,高于对照组的78.58%(P<0.05)。治疗后,两组的CRP、TNF-α、IL-6、Lep水平均降低,且试验组低于对照组(P<0.05)。治疗后,两组的胆囊厚度均小于治疗前,胆囊收缩率均增高(P<0.05);治疗后,试验组胆囊厚度比对照组小,胆囊收缩率比对照组高(P<0.05)。治疗后,两组VAS评分均低于治疗前,且试验组低于对照组(P<0.05)。两组不良反应发生率差异无统计学意义(P>0.05)。结论柴芍六君子汤联合茴三硫片治疗慢性胆囊炎疗效显著,可降低患者体内的炎症反应水平,改善胆囊收缩功能,减轻患者的腹痛,且安全性良好。
Objective To investigate the effects of chaishao liujunzi decoction combined with anethol trithione tablets on abdominal pain,gallbladder systolic function and inflammatory response of patients with chronic cholecystitisin.Methods Select 84 patients with chronic cholecystitis in Kaifeng Second Traditional Chinese Medicine Hospital from January 2022 to January 2024 and they were randomly divided into control group and experimental group,with each group have 42 patients.The control group was treated with anethol trithione tablets,and the experimental group was treated with chaishao liujunzi decoction on the basis of the control group,all treated for 8 weeks.Compared the two groups in the total effective rate and incidence of adverse reactions,and serum inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),leptin(Lep)]levels,gallbladder thickness,gallbladder shrinkage and abdominal pain degree[Visual Analogue Scale(VAS)]before and after treatment.Results The experimental group of the total effective rate was 92.86%,was higher than the control group(78.58%)(P<0.05).The levels of CRP,TNF-α,IL-6 and Lep in 2 groups were decreased after treatment,and the experimental group was lower than the control group(P<0.05).Gallbladder thickness decreased and gallbladder shrinkage rate increased in 2 groups after treatment(P<0.05),the experimental group was lower in the gallbladder thickness than control group after treatment,and the gallbladder shrinkage rate was higher than control group(P<0.05).After treatment,the VAS scores of 2 groups were decreased,and the experimental group was lower than the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Chaishao liujunzi decoction combined with anethol trithione tablets has significant efficacy in the treatment of chronic cholecystitis,which can significantly reduce the inflammatory response in patients,improve gallbladder symptoms and alleviate abdominal pain in patients with good safety.
作者
张珍
曹丹凤
ZHANG Zhen;CAO Danfeng(Kaifeng Second Traditional Chinese Medicine Hospital,Kaifeng Henan 475000,China)
出处
《药品评价》
CAS
2024年第8期1011-1014,共4页
Drug Evaluation
关键词
柴芍六君子汤
茴三硫片
慢性胆囊炎
腹痛程度
胆囊收缩功能
炎症反应
Chaishao liujunzi decoction
Anethol trithione tablets
Chronic cholecystitis
Degree of abdominal pain
Gallbladder systolic function
Inflammatory response
