摘要
目的探讨血清激肽释放酶6(KLK6)、脂联素(APN)与帕金森病患者认知功能障碍的相关性。方法选取徐州医科大学附属医院收治的112例帕金森病患者,依据认知功能障碍情况分为发生组(帕金森病合并认知障碍组,44例)和未发生组(帕金森病认知功能正常组,68例),采用酶联免疫吸附法检测血清KLK6、APN水平,比较2组血清KLK6、APN水平,相关性、影响因素、预测价值分别采用Pearson法、Logistic回归及受试者工作特征(ROC)曲线分析。结果Pearson相关性分析显示,血清KLK6、APN分别与MMSE评分、MoCA评分呈负、正相关(P<0.05)。Logistic回归分析显示,帕金森病程长、修订Hoehn-Yahr分级晚期、血清KLK6高水平均是影响帕金森病患者发生认知功能障碍的危险因素,血清APN高水平是其保护性因素(P<0.05)。ROC曲线分析显示,血清KLK6、APN水平联合预测的曲线下面积为0.960,灵敏度、特异度分别为90.91%、89.71%(P<0.05)。结论帕金森病合并认知功能障碍患者血清KLK6升高、APN降低,血清KLK6、APN不仅与认知功能相关,还是帕金森病患者发生认知功能障碍的影响因素,两者联合预测帕金森病认知功能障碍有较高的临床价值。
Objective To investigate the relationship between serum kallikrein 6(KLK6)and adiponectin(APN)and cognitive dysfunction in patients with Parkinsons disease.Methods Totally 112 patients with Parkinsons disease in the Affiliated Hospital of Xuzhou Medical University were selected and divided into the occurrence group(Parkinsons disease with cognitive impairment group,44 cases)and the non-occurrence group(Parkinsons disease with normal cognitive function group,68 cases)according to the cognitive dysfunction.The levels of serum KLK6 and APN were detected by enzyme-linked immunosorbent assay,and the differences between the two groups were compared.Pearson correlation analysis,Logistic regression and ROC curve analysis were used for correlation,influencing factors and predictive value,respectively.Results Pearson correlation results showed that serum KLK6 and APN were negatively and positively correlated with MMSE score and MoCA score,respectively(P<0.05).Logistic regression analysis showed that the long course of Parkinsons disease,the late revision of Hoehn-Yahr classification and the average high level of serum KLK6 were the risk factors for cognitive dysfunction in patients with Parkinsons disease,and the high level of serum APN was its protective factor(P<0.05).ROC curve analysis showed that the area under the curve of the combined prediction of serum KLK6 and APN levels was 0.960,and the sensitivity and specificity was 90.91%and 89.71%,respectively(P<0.05).Conclusion In patients with Parkinsons disease complicated with cognitive dysfunction,serum KLK6 increases and APN decreases.Serum KLK6 and APN are not only related to cognitive function,but also are influencing factors for cognitive dysfunction in patients with Parkinsons disease.The combination of them has high clinical value in predicting cognitive dysfunction of Parkinsons disease.
作者
孙迎迎
龚梦茜
张伟
梁晓倩
孙超
崔桂云
SUN Yingying;GONG Mengqian;ZHANG Wei;LIANG Xiaoqian;SUN Chao;CUI Guiyun(The Affiliated Hospital of Xuzhou Medical University,Xuzhou 221000,China)
出处
《中国实用神经疾病杂志》
2025年第1期23-27,共5页
Chinese Journal of Practical Nervous Diseases
基金
江苏省卫生健康委科研课题(编号:BJ23028)。
关键词
帕金森病
认知功能障碍
激肽释放酶6
脂联素
相关性
影响因素
预测价值
Parkinsons disease
Cognitive dysfunction
Kallikrein 6
Adiponectin
Relevance
Influencing factors
Predictive value
