摘要
目的探究新冠肺炎患者临床-影像资料中可预测其胸部CT早期进展的指标。方法40例咽拭子核酸检测阳性的新冠肺炎患者纳入本回顾性研究,按照随访时(确诊后6±2天)患者胸部CT的转归,分为早期进展组(19例)和非早期进展组(21例),并收集确诊日患者的临床、实验室数据和胸部CT资料,通过统计学分析找出潜在预测新冠肺炎患者胸部CT早期进展的指标。结果早期进展组患者淋巴细胞百分比明显低于非早期进展组(P<0.05)。早期进展组患者在确诊日的胸部CT中更多出现胸部实变征象和心包积液(P均<0.05)。Binary Logistic回归分析显示,确诊日胸部CT中实变征象与胸部CT早期进展具有相关性(P=0.023,OR=9.52,95%CI:1.3669-66.1794)。胸部CT出现实变征象的ROC曲线下面积为0.716(95%CI:0.551-0.847)。淋巴细胞百分比、胸部CT实变征象和心包积液联合ROC曲线下面积为0.870(95%CI:0.725-0.955)。结论新冠肺炎患者确诊日胸部CT中出现实变征象、心包积液和实验室检查结果中的淋巴细胞百分比减低可预测其早期胸部CT进展,为临床诊治新冠肺炎患者提供预警信息。
Objective This study aimed to find out the clinical-imaging predictors which are potentially related with the early progression of chest CT from COVID-19 patients.Methods 40 patients with COVID-19 confirmed with the positive new coronavirus nucleic acid antibody included in this study.Patients were divided into two groups of early-progression(19cases)and non-progression depending(21cases)on the variations of CT findings between two CT scans.The imaging findings,clinical and laboratory data were evaluated at the first day of their admission.Imaging manifestations on chest CT were followed-up at(6±2)days.Then all data were analyzed using method of statistics and try to find out predictors that potentially related with the early progression of chest CT from COVID-19 patients.Results The lymphocyte percentage was significantly lower in the earlyprogression group than the non-progression group(P<0.05).Compared to non-progression group,early-progression group showed more signs of concentration(which plays a bigger part,more than 50%,among imaging results of the chest CT)and pericardial effusion(all P<0.05).The binary enter logistic regression model revealed a significant correlation of consolidation with early progression of chest CT(P=0.023,OR=9.52,95%CI:1.3669-66.1794).Furthermore,the area under the ROC curve for consolidation was 0.716(95%CI:0.551-0.847),and the area under the combined ROC curve for lymphocyte percentage,consolidation and pericardial effusion was 0.870(95%CI:0.725-0.955).Conclusion Lymphocyte percentage,consolidation and Pericardial effusion could be used to predict early progression on chest CT from COVID-19 patients.
作者
李灿
LI Can(CT and MRI Center,Juancheng People’s Hospital,Juancheng 274600,Shandong Province,China)
出处
《罕少疾病杂志》
2024年第12期45-47,共3页
Journal of Rare and Uncommon Diseases
