摘要
目的:分析血清3-羧基-4-甲基-5-丙基-2-呋喃戊酮酸(CMPF)在不同糖代谢人群中与胰岛素抵抗的关联。方法:选择已经建立的上海市常住居民糖尿病筛查资料库进行分析。纳入新诊断2型糖尿病(T2DM组)患者、糖耐量正常者(NGT组)、糖调节受损者(IGR组)各100例。采用酶联免疫吸附法测定血清CMPF水平。运用统计学方法分析CMPF与胰岛素抵抗之间的关系。结果:CMPF在NGT组、IGR组、T2DM组中逐渐升高;T2DM组和IGR组的稳态模型胰岛素抵抗指数(HOMA-IR)均高于NGT组;稳态模型胰岛素分泌指数(HOMA-β)、胰岛素分泌一相指数、胰岛素分泌二相指数、DI30、DI120在三组中依次降低(P<0.001)。Pearson相关性分析显示,血清CMPF与HOMA-IR呈正相关(P<0.05),与HOMA-β、胰岛素分泌一相指数、DI30呈负相关(P<0.05)。二元逻辑回归分析结果显示,在校正了性别、年龄、体重指数后,血清CMPF是胰岛素抵抗加重风险的相关因素[OR=2.743(1.553,4.846),P<0.001]。结论:不同糖代谢状态人群的循环CMPF水平不同;CMPF在糖代谢异常人群水平升高,与胰岛素抵抗呈正相关。然而,其潜在的因果关联仍需进一步研究阐明。
Objective To analyze the relationship between serum 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid(CMPF)and insulin resistance in patients with different glucose metabolism.Methods The established diabetes screening database of permanent residents in Shanghai was selected for analysis.The newly diagnosed T2DM patients(T2DM group),residents with normal glucose tolerance(NGT group)and those with impaired glucose regulation(IGR group)were includ⁃ed according to gender,age,and body mass index,100 in each group.Serum CMPF was determined by enzyme-linked im⁃munosorbent assay.The relationship between CMPF and insulin resistance was analyzed using statistical methods.Results CMPF increased gradually in the NGT group,IGR group,and T2DM group.Homeostasis model assessment of insulin re⁃sistance index(HOMA-IR)in the T2DM and IGR groups was higher than that in the NGT group.Homeostasis model as⁃sessment of beta-cell function(HOMA-β),first-phase insulin secretion,second-phase insulin secretion,DI30,and DI120 decreased successively in the three groups(all P<0.001).Pearson correlation analysis showed that serum CMPF was positively correlated with HOMA-IR(P<0.05),and negatively correlated with HOMA-β,first-phase insulin secretion,and DI30(P<0.05).The binary logistic regression revealed that serum CMPF was associated with the progressive exacerba⁃tion of insulin resistance after adjusting for gender,age,and body mass index[OR=2.743(1.553,4846),P<0.001].Conclusion CMPF differed in people with different glucose metabolism.It increased in people with abnormal glucose me⁃tabolism and was positively correlated with insulin resistance.However,further research is needed to clarify the potential causal link.
作者
刘禄萍
于雪梅
张珊
李雪
郑丽妹
陈培红
LIU Lu-ping;YU Xue-mei;ZHANG Shan;LI Xue;ZHENG Li-mei;CHEN Pei-hong(Anhui University of science and Technology,Huainan,Anhui 232001;Department of Endocrinology and Metabolism,Fengxian District Central Hospital,Shanghai 201406,China)
出处
《湖北医药学院学报》
CAS
2024年第6期662-667,共6页
Journal of Hubei University of Medicine
基金
上海市卫健委课题(202040182)
上海市奉贤区科委课题(20191217)。
