摘要
昆虫短神经肽F(short neuropeptide F,sNPF)是一类昆虫体内特有的神经肽,因其C末端为苯丙氨酸(F)而得名,由6~19个氨基酸构成,C末端为保守的精氨酸-亮氨酸-精氨酸-苯丙氨酸(RLRFamide)结构。sNPF在昆虫中参与调控进食、生长发育、生物钟、水盐平衡等多种生理活动。其受体属于A类G蛋白偶联受体(GPCR-As),具有典型的7个跨膜结构域特征,sNPF通过与其受体sNPFRs结合,在昆虫神经系统中发挥着重要的调节作用。本文主要介绍sNPF的结构与功能等相关研究进展,以及该类神经肽在害虫防治方面的潜在应用,以期为以sNPF为基础进行先导化合物的设计和改造、研究开发新型绿色农药提供指导,为农业害虫防治提供新的思路和方法。
Insect short neuropeptide F(sNPF)is a class of neuropeptides unique to insects,named for its C-terminal phenylalanine(F).These peptides are composed of 6-19 amino acids and have a conserved C-terminal RLRFamide structure.sNPF is involved in regulating various physiological activities in insects,including feeding,growth and development,circadian rhythms,water-salt balance.Its receptor is a class A G protein-coupled receptors(GPCR-As)with typical seven transmembrane domains.By binding to receptor sNPFRs,sNPF plays an important regulatory role in the insect nervous system.This article primarily reviews the research progress on sNPF,including its structure and function,as well as the potential applications in pest control.The aim is to provide guidance for the design and modification of lead compounds based on short neuropeptide sNPF,as well as supporting the research and development of novel green pesticides,thereby offering new ideas and methods for agricultural pest management.
作者
周源琳
王淳钥
吉庆东
刘安治
穆开心
冉文亿
ZHOU Yuanlin;WANG Chunyue;JI Qingdong;LIU Anzhi;MU Kaixin;RAN Wenyi(College of Chemical Engineering,Sichuan University of Science&Engineering,Zigong 643000,Sichuan Province,China)
出处
《农药学学报》
CAS
CSCD
北大核心
2024年第6期1025-1036,共12页
Chinese Journal of Pesticide Science
基金
四川省自然科学基金项目(2024NSFSC1323)。
