摘要
肝衰竭与肠道菌群紊乱及胆汁酸代谢异常密切相关。基于中医气机升降理论,发现“土壅木郁”是肝衰竭的主要病机。“土壅”指脾失健运,与肠道菌群紊乱密切相关;“木郁”指肝失疏泄,常伴随胆汁酸代谢异常。现代医学“肠-肝轴”理论可揭示肠道菌群与胆汁酸间的动态平衡对肝脏健康的重要性。西医研究发现,“肠道菌群-胆汁酸互作”的失调可能与肝脏疾病的发生机制有关。基于此,本文结合该视角,阐明肝衰竭中中医“土壅木郁”病理机制的生物学基础,为深入理解“土壅木郁”的病机实质及促进中医药在预防和治疗肝衰竭方面开辟新思路。
Hepatic failure is closely associated with the dysregulation of intestinal microbiota and the imbalance of bile acid metabolism.Based on the theory of qi rise and fall in traditional Chinese medicine,it has been found that“earth congestion and wood stagnation”is the main pathogenesis of liver failure.“Earth congestion”refers to dysfunction of spleen in transportation,which is closely related to the dysregulation of intestinal microbiota;“wood stagnation”refers to the dysfunction of liver in conveyance and dispersion,often accompanied by bile acid metabolism disorders.The theory of“gut-liver axis”in modern medicine can reveal the importance of dynamic balance between gut microbiota and bile acids for liver health.Western medicine research has found that the imbalance of“intestinal microbiota-bile acid interaction”may be related to the mechanism of liver disease occurrence.Based on this,this article combines this perspective to clarify the biological basis of the pathological mechanism of traditional Chinese medicin’s“earth congestion and wood stagnation”in liver failure,in order to deepen the understanding of the pathological essence of“earth congestion and wood stagnation”and promote new ideas for traditional Chinese medicine in the prevention and treatment of liver failure.
作者
杨雪梦
尹东豪
张丽丽
胡建华
YANG Xuemeng;YIN Donghao;ZHANG Lili;HU Jianhua(Center for Integrative Chinese and Western Medicine,Beijing You’an Hospital,Capital Medical University,Beijing100069,China)
出处
《中国医药导报》
CAS
2024年第32期166-169,共4页
China Medical Herald
基金
北京市医院管理局重点医学专业发展计划项目(ZYLX201819)。
关键词
肝衰竭
肠道菌群
胆汁酸
“土壅木郁”
Hepatic failure
Intestinal microbiota
Bile acid
“Earth congestion and wood stagnation”
