摘要
目的:研究参桂强心汤治疗慢性心力衰竭(CHF)气虚血瘀痰饮证患者疗效。方法:选取72例CHF气虚血瘀痰饮证患者,随机分成两组,对照组(n=36)采用西医标准治疗,治疗组(n=36)在对照组的基础上增加参桂强心汤加减治疗。观察比较两组患者疗效与中医证候积分、左心室射血分数(LVEF)、N末端脑钠肽前体(NT-proBNP)水平、血管内皮功能、明尼苏达心衰量表积分(MLHFQ)及6MWT。结果:治疗组治疗总有效率明显高于对照组(P<0.05)。治疗后两组中医证候积分显著下降,治疗组下降更明显(均P<0.05)。治疗后,两组LVEF与NT-proBNP水平明显改善,且治疗组LVEF更高,NT-proBNP水平更低(均P<0.05)。治疗后两组VEGF水平升高,ET-1水平降低,相较对照组,治疗组VEGF水平更高,ET-1水平更低(均P<0.05)。治疗后,两组MLHFQ积分、6MWT改善,且治疗组MLHFQ积分更低,6MWT更高(均P<0.05)。结论:参桂强心汤加减治疗CHF气虚血瘀痰饮证患者能有效改善其中医证候积分、提高中医证候疗效,改善LVEF和NT-proBNP水平、血管内皮功能、MLHFQ积分、6MWT。
Objective:To study the curative effect of Shengui Qiangxin decoction on patients with chronic heart failure(CHF)syndrome of Qi deficiency,blood stasis and phlegm.Methods:72 patients with CHF syndrome of Qi deficiency and blood stasis and phlegm drink were randomly divided into two groups.The control group(n=36)received conventional drug treatment,and the treatment group(n=36)received Shengui Qiangxin decoction treatment on the basis of the control group.Traditional Chinese medicine syndrome scores,therapeutic effects,left ventricular ejection fraction(LVEF),NT-proBNP level,vascular endothelial function,the Minnesota Living with Failure Questionnaire(MLHFQ)scores,and 6MWT of the two groups were compared.Results:The total effective rate of the control group was significantly lower than that of the traditional Chinese medicine group(P<0.05).After treatment,LVEF and NT-proBNP levels of the two groups were significantly improved,and LVEF level of the treatment group was higher than that of the control group,NT-proBNP level was lower than that of the control group(all P<0.05).After treatment,VEGF level increased,ET-1 level decreased,VEGF level in treatment group was higher than that in control group,ET-1 level was lower than that in control group(all P<0.05).After treatment,the MLHFQ score and 6MWT of the two groups were improved,and the MLHFQ score of the treatment group was lower than that of the control group,and the 6MWT score was higher than that of the control group(all P<0.05).Conclusion:Shengui Qiangxin decoction can effectively improve the TCM syndrome score,improve the efficacy of TCM syndrome,improve the level of LVEF,NT-proBNP and vascular endothelial function,MLHFQ score and 6MWT results in patients with CHF Qi deficiency and blood stasis syndrome.
作者
杨文萍
杨丹
唐海君
蒋莹
彭艳
范小春
YANG Wenping;YANG Dan;TANG Haijun;JIANG Ying;PENG Yan;FAN Xiaochun(Nanchong Hospital of Traditional Chinese Medicine,Nanchong 637000,China)
出处
《陕西中医》
CAS
2024年第12期1654-1657,共4页
Shaanxi Journal of Traditional Chinese Medicine
基金
四川省中医药管理局科研项目(2024MS614)
四川省南充市科技应用基础研究项目(23YYJCYJ0127)
医学影像四川重点实验室科研资金资助项目(MIKL202309)。
